| Purpose: This study mainly focuses on the patients with mild and moderate large intestine moist heat ulcerative colitis.Two groups of patients will be observed regarding to the improvement of TCM syndrome score,inflammatory index(CRP,ESR),quality of life(IBD-Q),anxiety and depression state(SAS,SDS)etc.before and after treatment.And the clinical efficacy of TCM decoction combined with auricular point pressure bean was discussed.This study provides reference for UC clinical treatment.Material and method: From December 2021 to December 2022,60 patients who met the Eligibility Criteria have been collected and randomly grouped,including 30 cases in the auricular acupoint group and 30 cases in the traditional Chinese medicine group.The traditional Chinese medicine group was given oral Qingchang Yuyang Decoction(means‘Clear Heat and Astring the Bowel Decoction’)and retention enema with self-prepared Qingre Qushi prescription(means ‘eliminating heat and wetness evil therapy’).On the basis of the traditional Chinese medicine group,the auricular acupoint group lasts 2 weeks treatment repectively with ear acupoint pressure bean treatment.Excel database was established to observe and record TCM syndrome score,inflammatory indicators(CRP,ESR),quality of life(IBD-Q),anxiety and depression status(SAS,SDS),clinical efficacy and other data before and after treatment,and SPSS26.0 statistical software was used to analyze the data.Results:1.Comparison in TCM syndrome: The auricular point group achieved 96.66% efficiency,and the TCM group 86.67%;The TCM syndrome in both groups was significantly improved.And the result of auricular point group was superior to the one of TCM group.The difference was significant in statistic field.(P <0.05).2.Comparison in TCM scores: After treating patients in two group,the total scores and individual scores shows obviously increase compared with the states before treatment,indicating that the difference make senses in statistic field and treatments in both groups is effective.Meanwhile,the auricular point group was advantage over the Chinese medicine group in diarrhea,mucous,pus and blood stools,abdominal pain,posterior tendrine and acute diseases,anal burning,abdominal distension,dry mouth and bitter mouth,and the difference was statistically significant(P <0.05).3.Comparison in clinical efficacy: A total of 36 patients undergoing colonoscopy were followed up in this study,including 17 patients in the auricular point group undergoing colonoscopy and 13 patients who did not undergo colonoscopy.The endoscopic review rate was 56.67%.In the traditional Chinese medicine group,the number of re-examination was 19,and the number of non-re-examination was 11,and the re-examination rate of endoscopy was63.33%.According to the results of colonoscopy return visit,the clinical efficacy was calculated by the modified Mayo score.In the auricular point group,10 cases were clinically relieved,6 cases were clinically effective and 1 case was clinically ineffective,with a total effective rate of 94.11%.In the TCM group,there were 4 cases of clinical remission,9 cases of clinical effective,6 cases of clinical ineffective,and the total effective rate was 68.42%.The clinical effect of auricular point group was better than that of TCM group(P < 0.05).4.Improved Mayo score: The improved Mayo score in both groups was effectively reduced after treatment(P < 0.05),and the auricle point group was better than the traditional Chinese medicine group in reducing the improved Mayo score(P < 0.05).5.Comparison in colonoscopy scores: After treatment,colonoscopy scores in both groups were significantly decreased,and the difference was statistically significant(P <0.05),and auricular point group was better than traditional Chinese medicine group in promoting mucosal healing(P <0.05).6.Comparison in inflammatory indexes: Serum ESR and CRP levels in 2 groups were decreased after treatment,both of which could improve inflammatory indexes(P < 0.05),and auricular point group was better than traditional Chinese medicine group(P < 0.05).After treatment,WBC level was decreased and HGB level was increased in both groups(P < 0.05),and the improvement effect of auricular point group was better than that of TCM group(P <0.05).7.Comparison in quality of life scores: There’s a significant increase in the total score of quality of life and scores of various aspects of patients.The quality of life improved(P<0.05)and takes an advantage over the Chinese medicine group in this aspect(P <0.05).8.Comparison in anxiety and depression: SAS and SDS scores of the two groups became less after treatment.Both groups could relieve the degree of anxiety and depression of patients(P<0.05),and the improvement of the auricular point group took advantage over that of the traditional Chinese medicine group(P <0.05).9.Safety indicators: No adverse reactions occurred in the two groups during treatment.The vital signs(body temperature,blood pressure,pulse,respiration,etc.)of the two groups were not significantly abnormal.No allergy to known drug ingredients or ear skin allergy occurred.Conclusion:1.Chinese medicine combined with ear point pressure bean and simple Chinese medicine treatment can effectively improve the curative effect of mild and moderate large intestine dampness and heat type UC,induce symptom relief,reduce inflammatory indicators,alleviate negative emotions,improve quality of life,and promote intestinal mucosal repair,and the curative effect of combined treatment is superior to that of simple Chinese medicine treatment.2.Auricular point pressure bean therapy is easy to learn,easy to operate,can be used to assist UC treatment and self-health care,worthy of further promotion and development.3.There is no adverse reaction in the treatment of UC by auricular acupoint pressure bean combined with traditional Chinese medicine decoction,and triple therapy can be selected for the clinical treatment of mild and moderate large intestine damp heat type UC. |
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