Effects Of Cangshan Sticking Umbilical Warming Method On The Outcome Of Frozen-thawed Embryo Transfer And Endometrial Receptivity Of Patients With Kidney Deficiency And Blood Stasis

Objective:To observe the effect of Cangshan umbilical warming method on the outcome of frozen-thawed embryo transfer and endometrial receptivity of patients with kidney deficiency and blood stasis,and also to provide a new method and idea for clinical application of external treatment in improving pregnancy outcome of FET and ER.Methods:A total of 109 patients who met the criteria from June 2019 to December 2020in the Reproductive Center of Shuguang Hospital were collected,Including Drug patch group（37 patients）,fever patch group（37 patients）,and control group（35 patients）.The control group received hormone replacement therapy for endometrium preparation.The fever patch group was added with a blank fever patch on the basis of the control group,and the Drug patch group was added with a Cangshan umbilical patch on the basis of the control group.Observation indicators:（1）General conditions:age,infertility years,infertility cause and type,BMI.（2）TCM syndrome index and total effective rate before and after treatment.（3）Laboratory indicators:FSH,LH,E₂,P on the 2-3 days of the menstrual cycle and embryo transfer day,β-HCG on the 14th day after FET.（4）Ultrasonic indicators:membrane thickness on the third day of the menstrual cycle,blood flow,thickness,PI,RI on the embryo transfer day,and 28 days after FET.（5）Pregnancy:implantation rate,pregnancy rate and continuous pregnancy rate.Results:（1）Comparison of TCM syndrome:After treatment,the three groups of patients were lower than before treatment（P<0.05）.After treatment,the comparison between the groups found that the Drug patch group was significantly lower than the control group（P<0.05）.（2）Comparison of curative effect of TCM syndromes:the total curative effect of Drug patch group was significantly higher than the fever patch group and the control group（P<0.05）.（3）Comparison of endometrial morphology and blood flow on the embryo transfer day:The blood flow of type A and type III of the Drug patch group was significantly higher than that of the fever patch group and the control group（P<0.05）.（4）Comparison of uterine artery PI and RI on the embryo transfer day:The PI and RI of the Drug patch group were lower than those of the control group（P<0.05）.（5）Comparison of pregnancy outcomes:For patients under 35 years of age,the implantation rate,pregnancy rate and continuous pregnancy rate of Drug patch group are higher than those of fever patch group and the control group.Except for the implantation rate who transplanted blastocysts and under 35 years of age（P<0.05）,the other differences were not statistically significant.Conclusion:For patients with kidney deficiency and blood stasis type FET on the basis of hormone replacement to prepare the endometrium,Cangshan umbilical patch and blank fever patch can increase the proportion of type A endometrium and type III blood flow,reduce the patient’s PI and RI,improve the clinical symptoms of patients in TCM and increase the effective rate,increase the embryo implantation rate,pregnancy rate and the trend of continuous pregnancy rate in patients under 35 years old,and the effect of Cangshan umbilical patch is better,which is worthy of clinical attention.