Clinical Observation Of Buqixingyutongnao Decoction In Treating Cerebral Infarction Of Qi Deficiency And Blood Stasis

Objective: This clinical observation is to observe the clinical eff icacy and safety of Buqi Xingyu Tongnao Decoction in the treatment of cerebral infarction with Qi deficiency and blood stasis.Methods:A total of 72 patients who visited the fourth Department of Encephalopathy(Department of Geriatrics)in Shijiazhuang Hospital of Traditional Chinese Medicine from February 2022 to August 2022 and were clinically diagnosed as convalescent cerebral infarction of Qi deficiency and blood stasis type were selected.The 72 subjects who participated in the clinical observation were divided into control group and treatment group,36 in each group.The control group was treated with aspirin,atorvastatin calcium,folic acid tablets,etc.In addition to the control group,the treatment group was also given Buqixingyutongnao decoction(provided by Shijiazhuang Hospital of Traditional Chinese Medicine-West Hospital Shenwei Medicine Free Room),twice a day,0.5hours after meals.4 weeks as a course of treatment,a total of 2 courses(8weeks)of clinical observation.Clinical efficacy and safety indexes,including blood Homocysteine(Hcy)level,NIHSS score,Barthel(BI)score,clinical efficacy evaluation,TCM symptom evaluation form and safety indexes,were observed and recorded before treatment,after one course of treatment and two courses of treatment.The recorded data were analyzed using the Chinese version of SPSS 25.0 software.The analyzed results were considered as not statistically significant if P > 0.05,and statistically significant if P < 0.05.To evaluate the clinical efficacy and safety of Buqixingyutongnao decoction.Results:1.Before this clinical observation,the gender,age and course of disease of the two groups were compared respectively,and the results showed that there were no significant differences in the above aspects between the two groups(P>0.05).2.In terms of clinical efficacy observation indicators,the clinical efficacy observation indicators of subjects in the two groups were compared in pairs before treatment,after 1course of treatment and after 2 courses of treatment.The results showed that before the clinical observation,there was no statistical significance in blood Hcy level,NIHSS score,BI score and TCM symptom score between the two groups(P>0.05).After 1 course of treatment,blood Hcy level,NIHSS score,BI score and TCM symptom score of subjects in 2 groups were improved compared with before treatment(P<0.05).The blood Hcy level and TCM symptom score of the treatment group were better than those of the control group(P<0.05).There was no significant difference in NIHSS score and BI score between the two groups(P>0.05).After 2courses of treatment,blood Hcy level,NIHSS score,BI score and TCM symptom score of subjects in 2 groups were improved before treatment and after 1 course of treatment(P<0.05).The blood Hcy level,NIHSS score,BI score and TCM symptom score of the treatment group were better than those of the control group(P<0.05).3.In terms of clinical efficacy evaluation,after 2 cycles of clinical observation,both groups achieved good efficacy,with the effective rate of 91.67% in the treatment group and77.78% in the control group,and the effective rate of the treatment group was higher(P<0.05).4.In terms of the observation of safety indicators,all subjects who participated in and completed this clinical observation showed no obvious abnormalities in general items(including body temperature,heart rate,respiration and blood pressure),tests and examination items(including blood routine,liver function,kidney function,blood lipid,blood glucose,electrolyte and electrocardiogram);In terms of adverse reactions,subjects in the two groups did not have significant adverse reactions during the clinical observation period,so relevant statistical analysis was not performed.Conclusion:In terms of clinical efficacy,oral Buqixingyutongnao decoction can significantly reduce the blood Hcy level of patients,improve patients’ NIHSS score,BI score and TCM symptom score,improve patients’ quality of life,reduce disease recurrence and improve prognosis.In terms of safety,Buqixingyutongnao Decoction has the characteristics of low side effects,reliable and convenient in clinical use,so it is worth promoting and applying in clinical practice.