Clinical Study On The Treatment Of Bronchial Asthma At Acute Attack Stage(mild To Severe)with Huanglong Cough Relief Granules Plus

Objective:The objectives of this study were to observe the efficacy and safety of Huanglong cough relief granules plus in the treatment of bronchial asthma at acute attack stage(mild to severe).Methods:The sixty-six patients who met the inclusion criteria during an acute exacerbation of bronchial asthma were randomized into two groups,the experimental group and the control group.Both groups were given conventional Western medicine basic treatment,including budesonide combined with terbutaline atomization,dihydroxypropylline intravenous drip and Montelukast sodium oral therapy,moderate to severe patients were given methylprednisolone intravenous anti-inflammatory therapy,and patients with bacterial infection were given anti-infection therapy with cefzoxime sodium.The experimental group was treated with oral Chinese medicine on the basis of the conventional Western medicine treatment in the control group,and the traditional Chinese medicine was treated with Huanglong cough relief granules plus as the basis for TCM differentiation.The treatment course of both two groups was seven days.The safety of medication was observed,and the TCM syndrome score,ACQ-7 score,pulmonary function test and other indicators of the two groups before and after treatment were compared,so as to evaluate the effectiveness and safety of Huanglong cough relief granules plus in the treatment of bronchial asthma at acute attack stage.Results:A total of 66 patients were included in this study,of which one patient in the experimental group automatically withdrew from the study due to early discharge,resulting in one case shedding.The last completed cases: thirty-two cases in the experimental group and thirty-three cases in the control group.Before the experiment,the basic data of the two groups such as gender,age,course of disease,severity of the disease,and antibiotic use were compared with various indicators such as TCM syndrome total score and individual score,ACQ-7 score,and pulmonary function tests,and none of the differences were statistically significant(all P>0.05),which was comparable.There were no significant adverse effects in either group of patients throughout the course of treatment.(1)Comparison of total effective rate: the total effective rate after treatment was 90.91% in the control group and 96.88% in the experimental group.The total effective rate of experimental group was higher than that of control group,and the difference was statistically significant(P < 0.05).(2)Comparison of the total scores of TCM syndromes: After treatment,the total scores of TCM symptoms in the experimental group and the control group decreased compared with before treatment,and the differences were statistically significant in the before and after comparison within the group(both P<0.05).After treatment,the total scores of TCM syndromes between the experimental group and the control group were statistically significant(P < 0.05),and the total scores of TCM syndromes in experimental group were lower than that of the control group.(3)Comparison of single scores of TCM syndromes: After treatment,the scores of single scores of TCM syndrome between the experimental group and the control group were both decreased compared with before treatment,and the differences between before and after comparison in the group were statistically significant(all P< 0.05).After treatment,the scores of wheezing,coughing and phlegm were statistically significant(all P<0.05)between the experimental group and the control group,and the scores of the experimental group were lower than those of the control group,and the difference in the scores of chest tightness and wheezing was not statistically significant(both P>0.05).(4)Comparison of ACQ-7 scores:After treatment,ACQ-7 scores of experimental group and control group were decreased compared with before treatment,and the difference between before and after treatment within the group was statistically significant(both P < 0.05);After treatment,ACQ-7 score of the experimental group and the control group was significantly different(P < 0.05),and the ACQ-7 score of the experimental group was lower than that of the control group.(5)Comparison of pulmonary function tests:After treatment,the FEV1%pred,FEV1/FVC and PEF in the experimental group and the control group increased compared with that before treatment,and the difference before and after treatment between the two groups was statistically significant(all P < 0.05);After treatment,the FEV1%pred,FEV1/FVC and PEF were statistically significant(all P<0.05)between the experimental group and the control group before and after treatment,and the FEV1%pred,FEV1/FVC and PEF in the experimental group after treatment were higher than those in the control group.Conclusion:The study have shown that Huanglong cough relief granules plus can effectively improve the symptoms of wheezing,coughing,phlegm and so on in patients with bronchial asthma at acute attack stage(mild to severe),reduce the ACQ-7 scores,and improve pulmonary ventilation function indexes such as FEV1%pred,FEV1/FVC,and PEF with good safety,and the efficacy of Conventional Western medicine combined with Huanglong cough relief granules plus in the treatment of bronchial asthma at acute attack stage(mild to severe)is better than that of Western medicine alone.