The Clinical Mechanism Research On Cough Variant Asthma In Children By Huanglong Mixture

Cough variant asthma (CVA), which is a common pediatric clinical disease, is known as a special type of asthma. Cough is the only or the main clinical manifestations, the irritating dry cough and night or morning cough are its important characteristics. Some factors, such as catching cold, dust,cold air and lampblack can result in or aggravate coughing. If there is no timely and effective treatment, some patients may develop into typical asthma. Its pathogenesis is not completely clear, many internal and external researchers have studied its pathogenesis from different aspects, they think that it relates to some factors such as inflammation, the high sensitivity of the airway, airway neural regulation, immunology, genetics, infectious and the environment factors, etc.Combining the clinical experience of my tutor, we think that the basic mechanism of the children’s CVA is invasion of the lung by wind-phlegm and adverse lung Qi of heat,and use the basic treatment of expelling wind and resolving tetany, clearing away heat from the lung and resolving phlegm, normalizing qi and downbearing counterflow. We applied Huanglong mixture to treat30children with CVA of invasion of the lung by wind-phlegm and adverse lung Qi of heat, and at the same time set up a team of Western medicine control group(Montelukast close with Terbutalin) to keep close observation over the patients in clinic.The result indicates that the numbers of the cases that were clinical control, significant effective, improved, ineffective in the treatment group were separately7(23.3%),14(46.7%),9(30.0%),0(0%), WhileO (0%),0(0%),11(55.0%),9(45.0%) in the comparison group; The total effectiveness rate of the treatment group was100%, while55.0%in the comparison group. With chi-square test, the difference of the total effectiveness rate between two groups was statistically significant(P＜0.01). Furthermore, after Chinese medicine therapy children eosinophils count and lung function (PEF) were significantly improved. At the same time, it provides beneficial enlightenment for the preliminary reveal on the treatment mechanism of this prescription.The study testifies the better efficiency of Huanglong mixture in treating CVA of invasion of the lung by wind-phlegm and adverse lung Qi of heat, which can improve clinical symptoms, is an effective and safe method. It provides good foundation for the further clinical research on Huanglong mixture.