| Objective: By observing the clinical data of the treatment of epilepsy complicated with depression disorder(liver depression and phlegm)with added Chaihu Kegu Oyster decoction,the therapeutic effect and safety of this prescription were judged.Methods: A total of 72 patients with epileptiform depressive disorder were selected from the Department of Encephalopathy,Affiliated Hospital of Changchun University of Traditional Chinese Medicine.The selected patients were randomly divided into the treatment group and the control group.On the basis of continuing to give the patients the same original antiepileptic drugs,The control group was treated with Shugan Jieyu Capsule(Chengdu Kanghong Pharmaceutical Group Co.,LTD.,approval number: Z20080580),and the treatment group was treated with added bupleurum keel and Oyster decoction(bupleurum,keel,scutellaria scutellaria,ginger,ginseng,cassia twig,poria cocos,pinellia pinellia,rhubarb,oyster,jujube,gastrodia elata,ground dragon,calamus stone and schisandra schisandra),and observed for 12 weeks.Corresponding indicators of the two groups of patients were recorded respectively to analyze the comparative data,so as to analyze and compare the efficacy of the two drugs.Statistical software SPSS26.0 was used to carry out statistical analysis and compare the difference before and after treatment.Results:(1)Comparison of HAMD scores at 6 weeks and 12 weeks after treatment between the two groups(in the treatment group,before treatment: 30.33±9.37,after 6 weeks: 20.10±5.59,after 12 weeks: 10.73±5.23;Control group,before treatment: 29.90±8.11,6 weeks after treatment: 24.13±4.97,12 weeks after treatment: 18.47±4.49),HAMD score decreased significantly compared with before treatment,with statistical significance(P<0.05);(2)Seizures: After 12 weeks of treatment,the number of seizures in both groups showed a significant downward trend,and the effective rates were 76.7% and 46.7%,respectively,with statistical significance(P<0.05).(3)Comparison of life quality scores: Modified Bupleurum Keel Oyster decoction combined with conventional AEDS improved the "seizure worry" and "life satisfaction" of epileptic patients better than Shugan Jieyu capsule combined with conventional AEDS,with statistical significance(P<0.05).(4)TCM syndroms: After 12 weeks of treatment,the relevant TCM syndroms of the treatment group and the control group were significantly improved,and the effective rates were 83.3% and 56.7%,respectively,with statistical significance(P<0.05).(5)Adverse reactions: The adverse reactions in the treatment group were as follows: gastrointestinal discomfort(n=2,accounting for 6.7%),drowsiness(n=1,accounting for 3.3%),constipation(n=1,accounting for 3.3%),dizziness(n=1,accounting for 3.3%),a total of 5 cases,the incidence of adverse reactions was 16.7%;In the control group,adverse drug reactions included gastrointestinal discomfort(n=3,10.0%),drowsiness(n=1,3.3%),constipation(n=1,3.3%),dry mouth(n=1,3.3%),dizziness(n=1,3.3%),a total of 7 cases,the incidence of adverse reactions was 23.3%.The difference was not statistically significant(P=0.506>0.05).No serious adverse events occurred in all patients,and symptoms improved after drug dosage reduction.Conclusion:(1)In the treatment of epilepsy patients with depression disorder(liver depression phlegm type),the modified Bupleurum Keel Oyster soup followed the treatment methods of soothing liver depression,regulating qi and eliminating phlegm,showing good clinical efficacy.(2)For patients with epilepsy complicated with depression disorder(liver depression phlegm type),on the basis of antiepileptic drugs,the use of bupleurum keel and oyster soup for treatment has fewer adverse reactions and higher safety. |
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