Clinical Study On Improved Bupleurum And Keel Oyster Decoction Combined With Its Jiangshi Method In Treating Insomnia Of Liver Depression And Phlegm-heat Internal Disturbance

Objective:The purpose of this study was to observe the efficacy and safety of modified bupleurum plus keel oyster decoction combined with Jiangshi therapy in the treatment of liver depression and phlegm-heat internal disturbance type insomnia.Methods:72 cases of insomnia patients with syndrome type of liver depression and phlegm-heat internal disturbance were collected,and were randomly divided into the treatment group(n=36 cases)and the control group(n=36 cases)according to the random number table method.All patients were given health education before treatment,and were instructed to keep a good mood and avoid fatigue,excitement and anxiety before going to bed.The control group was treated with dexzopiclone tablet orally.The treatment group was treated with modified bupleurum and keel oyster decoction combined with the rest method.Both groups were treated for 4 weeks.After the treatment course,relevant data were collected to observe the changes of Pittsburgh Sleep Quality Index(PSQI)score,Epworth Sleepiness Scale score and TCM syndrome score.Results :(1)PSQI score: Both groups showed efficacy in improving PSQI score.After treatment,the improvement of PSQI scores in the treatment group was better than that in the control group(P <0.001).The difference was statistically significant(P < 0.05).(2)Epworth score:Both groups improved daytime sleepiness,but the treatment group was better than the control group(P < 0.05).(3)TCM syndrome score: TCM syndrome score could be improved in both groups after treatment,but the treatment group was better than the control group(P < 0.05).(4)After treatment,the total effective rate of control group and treatment group was 82.9% and 91.4%,respectively.Conclusion:(1)Both groups can effectively reduce PSQI,Epworth and TCM syndrome scores of patients with liver depression and phlegm-heat internal disturbance type insomnia,and the treatment group is better than the control group.(2)Improved bupleurum and keel oyster decoction combined with jangshi method is more effective in the treatment of liver depression and phlegm-heat internal disturbance type insomnia,and this method is worth promoting.(3)No adverse reactions were found in the whole process of treating liver depression and phlegm-heat internal disturbance insomnia with improved bupleurum and keel oyster soup combined with janxi method,which is safe.