Clinical Efficacy Of Sheshang Capsule In The Treatment Of Abnormal Coagulation Due To Protobothrops Mucrosquamatus Viper Bites

ObjectiveTo investigate the efficacy of Sheshang capsule in treating coagulation abnormalities caused by proto-snake bites by observing the changes in laboratory indicators(tissue factor(TF),partial activation thromboplastin time(APTT)and prothrombin time(PT))and clinical efficacy of Sheshang capsule,to verify the clinical efficacy of Chinese medicine in treating venomous snake bites,and to better guide the clinical treatment of proto-snake bites.The clinical efficacy of Chinese medicine in the treatment of venomous snake bites was verified to better guide the clinical treatment of former spearhead viper bites.MethodsIn this study,72 cases of former spearhead viper bites were collected and randomly divided into a control group(n=36)and a treatment group(n=36).The control group was given basic snakebite treatment,while the treatment group was given Sheshang capsule in addition to the treatment regimen of the control group,and both groups were treated for 7days.The changes in the indexes and clinical efficacy of the two groups before and after treatment,as well as the presence of adverse reactions,were observed.After relevant statistical analysis,the clinical efficacy of Sheshang capsule in the treatment of the original spearhead pit viper bite was objectively evaluated.Results1.In this study,there was no statistically significant comparison between the baseline data and pre-treatment conditions of the two groups of patients(P>0.05).2.TF,APTT,PT: The differences between the two groups were statistically significant(P<0.05)when comparing day 3 and day 7 of treatment with pre-treatment,and when comparing day 3 of treatment with day 7 of treatment,all were lower than before,indicating that the treatment regimen of both groups could shorten TF,APTT and PT;the differences were statistically significant(P<0.05)when comparing the treatment group with the control group,indicating that the treatment group was better than the The difference was statistically significant(P<0.05),indicating that the treatment group was better than the control group.3.Pain scores: The differences between the two groups were statistically significant(P<0.05)on day 3 and 7 of treatment compared to before treatment,and on day 3 of treatment compared to day 7 of treatment,indicating that both groups were able to reduce local pain after the original spearhead viper bite;the differences between the treatment and control groups were statistically significant(P<0.05),indicating that the treatment group was superior to the control group.4.Swelling score: The difference between the two groups on day 3 of treatment and before treatment was statistically significant(P<0.05),and the swelling score was higher than before,indicating that the swelling in both groups on day 3 of treatment was worse than before treatment;the difference between the two groups on day 7 of treatment and before treatment and on day 3 of treatment was statistically significant(P<0.05),and the swelling score was significantly lower than before,indicating that the control group and the treatment group were more effective in improving The efficacy of the control and treatment groups in improving swelling symptoms was similar.The difference between the treatment and control groups was statistically significant(P<0.05),indicating that the treatment group was more effective than the control group in improving swelling on the third day of treatment;the difference between the groups before treatment and on the seventh day of treatment was not statistically significant(P>0.05),indicating that the two groups were comparable,and the difference between the control and treatment groups in improving swelling on the seventh day of treatment was statistically significant(P<0.05).The efficacy of the control group and the treatment group in improving swelling on day 7 was comparable.5.Overall efficacy score: The difference between the two groups on day 7 of treatment and before treatment was statistically significant(P<0.05),indicating that both groups were able to improve pain,swelling and coagulation function;the difference between the two groups on day 7 of treatment was statistically significant(both P<0.05),indicating that the treatment group was better than the control group.6.Total clinical efficacy: 27 cases were cured in the treatment group,9 cases showed efficacy,0 cases were effective,0 cases were invalid,the total efficiency was 100%;9 cases were cured in the control group,23 cases showed efficacy,4 cases were effective,0 cases were invalid,the total efficiency was 100%,the difference between the two groups was statistically significant(P<0.05).7.Assessment of adverse reactions and safety indicators: No serious adverse reactions occurred during the treatment period in both groups,and no abnormalities were found in the safety indicators.ConclusionSheshang capsule can effectively improve the coagulation index of the patient after the original spearhead viper bite,relieve local pain and effectively reduce the swelling of the injured limb in the pre-bite stage.No adverse reactions occurred during the treatment period and the safety of the capsule is high,which is worthy of further clinical application.