| ObjectiveBy observing the effects of internal administration of the Thirteen Flavors of Snake Injury Formula on the pain,swelling,symptom and sign scale,cardiac enzyme profile(Aspartate Transaminase,AST;Creatine Kinase,CK;Creatine kinase-MB isoenzyme,CK-MB;Lactate dehydrogenase,LDH)and Hypersensitive C-Reactive Protein(hs-CRP),to explore the clinical efficacy of the Thirteen Flavors of Snake Injury Formula on the clinical treatment of snake bites with fire and poisonous evidence and the changes of cardiac enzyme spectrum,to further promote the application and transmission of Chinese medicine experience formula,in order to better guide the clinical treatment of snake bites.MethodsSeventy-two patients who met the inclusion criteria and were admitted to the Department of Sore and Snake Injury and Vascular Surgery of the Affiliated People’s Hospital of Fujian University of Chinese Medicine were randomly divided into a treatment group and a control group.The control group was given routine treatment of snakebite,and the treatment group was treated with the Thirteen Flavors of Snakebite formula on the basis of the treatment plan of the control group,and both groups were treated for one week;the changes of the indexes and the presence of adverse reactions before and after treatment were observed and recorded in both groups.Statistical software was used for comparison and analysis,and conclusions were drawn.ResultsA total of 72 cases were completed in this case study,and the general baseline information and pre-treatment conditions of the two groups were compared,and the differences were not statistically significant(P>0.05)and could be compared.The study results and analysis are as follows:1.Degree of swelling: Limb swelling peaked on day 3 of treatment in both groups and gradually decreased thereafter.Comparison of different time points within groups: the difference was statistically significant(P<0.05)when compared with pre-treatment on day 3of treatment and decreased on day 7 of treatment compared with pre-treatment and day 3 of treatment.Comparison between groups at the same time points: the difference was statistically significant(P<0.05)compared with day 7 of treatment in both groups,indicating that the improvement of limb swelling in the treatment group was better than that in the control group2.Pain level: Comparison of different time points within the group: the difference was statistically significant(P<0.05)on the 7th day of treatment compared with the pre-treatment day and the 3rd day of treatment,with an overall decreasing trend;comparison of the same time points between groups: the difference was statistically significant(P<0.05)on the 3rd day of treatment and the 7th day of treatment,indicating that the pain relief in the treatment group was better than that in the control group.3.Serum AST and LDH levels: In both groups,the peak was reached on day 3 of treatment,and then gradually decreased.Within group comparison at different time points:AST and LDH decreased on day 7 of treatment compared to day 3 of treatment,and the differences were statistically significant(P<0.05).The differences were statistically significant(P<0.05)between groups at the same time points: AST on day 7 of treatment and LDH on day 3 and 7 of treatment,indicating that the reduction of AST and LDH in the treatment group was better than that in the control group.4.Serum CK and CK-MB levels: Both groups showed a gradual decrease with treatment time.The differences were statistically significant(P<0.05)when comparing different time points within groups: CK and CK-MB decreased on day 3 and day 7 of treatment compared to before treatment.Comparing the same time points between groups: CK on day 3 and 7 of treatment,and CK-MB on day 3 of treatment,the differences were statistically significant(P<0.05),indicating that the reduction of CK and CK-MB in the treatment group was better than that in the control group.5.Hypersensitive C-reactive protein levels: Both groups showed a gradual decrease with treatment time.The difference between groups was statistically significant(P<0.05)when compared on day 3 of treatment,indicating that the reduction of hs-CRP in the treatment group was better than that in the control group.6.Symptom and sign score scale: The differences were statistically significant(P<0.05)when comparing the two groups on the 7th day of treatment and before treatment and when comparing the two groups between the two groups on the 7th day of treatment,indicating that the symptoms of both groups improved after treatment and the treatment group improved better than the control group.7.Overall clinical efficacy: the overall effective rate was 84% in the control group and94% in the treatment group,with statistically significant differences between the two groups(P<0.05),and the clinical apparent efficiency of the treatment group was better than that of the control group.ConclusionThe formula can effectively improve the clinical symptoms such as pain and swelling,regulate the peripheral blood myocardial enzyme profile and the level of super-sensitive C-reactive protein in patients with fire and venomous snake bites. |
PDF Full Text Request