| Objective:1.Understand the current status of vitamin D in Tibetan children with pneumonia.2.Explore the correlation between Tibetan children with pneumonia and vitamin D levels,understand the correlation between vitamin D levels and the course and prognosis of pneumonia,and intervene in a timely manner.To shorten the course of the disease,reduce the occurrence of complications,and improve the survival rate of children with severe pneumonia.3.Explore some factors that affect vitamin D levels in Tibetan children with pneumonia,and provide guidance for clinical work.Methods:1.Select Tibetan children aged 2-6 who were diagnosed with pediatric pneumonia in the pediatric department of the People’s Hospital of Tibet Autonomous Region from June 2020 to May 2021 as the research subjects.Exclude individuals with obvious and severe brain,heart,and kidney diseases;Individuals with concomitant genetic metabolic diseases;Clinical data missing items;Children with immune deficiency disorders;Severe rickets.According to the serum 25(OH)D levels,they were divided into a normal vitamin D group,a vitamin D deficient group,and a vitamin D deficient group.The differences in vitamin D levels among the three groups were compared.According to the severity of pneumonia,calculate and compare the differences in the proportion of severe pneumonia among groups.Analyze the relationship between the severity of pneumonia and vitamin D levels.2.Select 2-6 year old Tibetan children who were hospitalized in the pediatric department of the People’s Hospital of Tibet Autonomous Region from June 2021 to June2022.Divide them into a pneumonia group and a non pneumonia group,and analyze the correlation between vitamin D levels in children with pneumonia and their living area,whether the mother supplements vitamin AD during the perinatal period,feeding methods within 6 months after birth,daily milk volume before 2 years old,and whether fortified foods are supplemented between 6 months and 2 years old.Compare the difference in vitamin D levels between the pneumonia group and the non pneumonia group.According to the severity of pneumonia,children in the pneumonia group were further divided into two subgroups:mild and severe,and the differences in vitamin D levels among children with pneumonia of different severity were analyzed and compared.Analyze the relationship between vitamin D levels and the severity of pneumonia in the pneumonia group.Results:1.From June 2020 to May 2021,there were a total of 200 hospitalized Tibetan pediatric pneumonia patients aged 2-6 who met the standards admitted to the Pediatric Department of the People’s Hospital of Tibet Autonomous Region.Among them,64children with pneumonia had normal vitamin D,with a normal vitamin D rate of 32.00%;80 children with pneumonia had insufficient vitamin D,with a vitamin D deficiency rate of40.00%;56 children with pneumonia had vitamin D deficiency,with a vitamin D deficiency rate of 28.00%.There is no statistical difference in the gender composition of clinical data among the three groups of vitamin D normal group,vitamin D deficiency group,and vitamin D deficiency group(χ~2=0.081,P=0.960>0.05).In terms of age distribution,there was no statistical difference in the overall age distribution among the three groups(H=2.984,P=0.225>0.05).2.There were 64 children in the normal vitamin D group,with serum 25(OH)D levels of 24.55(21.90,29.20)ng/m L;There are a total of 80 children in the vitamin D deficiency group,with serum 25(OH)D levels of 15.40(13.85,18.00)ng/m L;There were 56 children in the vitamin D deficiency group,with serum 25(OH)D levels of 9.45(6.73,10.57)ng/m L.There was a statistically significant difference in the overall distribution of vitamin D levels among the three groups of pneumonia patients(H=175.393,P<0.05).There were statistically significant differences in vitamin D levels between the vitamin D normal group and the vitamin D deficient group,between the vitamin D normal group and the vitamin D deficient group,and between the vitamin D deficient group and the vitamin D deficient group(P<0.05).3.By comparing the severity of the disease among the three groups of children with pneumonia,namely the vitamin D normal group,vitamin D deficiency group,and vitamin D deficiency group,there were a total of 64 children in the vitamin D normal group,of which 8 were severe cases,and severe pneumonia accounted for 12.50%(8/64);Among the80 cases of vitamin D deficiency group,43 cases had severe pneumonia,accounting for53.75%(43/80);There were 56 cases of vitamin D deficiency,48 cases of severe pneumonia,and 85.71%(48/56)of severe pneumonia.There is a statistically significant difference in the proportion of severe pneumonia among the three groups of vitamin D normal group,vitamin D deficiency group,and vitamin D deficiency group(χ~2=65.008,P<0.05).There is a statistically significant difference in the proportion of severe pneumonia among the three groups of vitamin D normal group,vitamin D deficiency group,and vitamin D deficiency group(χ~2=26.450,64.324,15.202,P<0.05).The Spearman rank correlation results showed a negative correlation between the severity of pneumonia in children and vitamin D levels(r=-0.620,P<0.05).4.From June 2021 to June 2022,there were a total of 200 hospitalized Tibetan children aged 2-6 who met the standards admitted to the Pediatric Department of the People’s Hospital of Tibet Autonomous Region.Among them,there are 100 cases in the pneumonia group and 100 cases in the non pneumonia group.The vitamin D level of children in the pneumonia group is related to factors such as their living area,whether their mother supplements vitamin AD during the perinatal period,feeding methods within 6months after birth,daily milk volume before 2 years old,and whether they supplement fortified foods between 6 months and 2 years old,all of which have statistical significance(P<0.05).The average serum 25(OH)D value in children with pneumonia was(17.34±8.11)ng/m L;The average serum 25(OH)D value of children in the non pneumonia group was(21.44±6.52)ng/m L.There was a statistically significant difference in vitamin D levels between the pneumonia group and the non pneumonia group children(t=3.939,P<0.05).5.Comparing the general information and vitamin D levels of mild and severe pediatric pneumonia patients in the hospitalized group from June 2021 to June 2022,there was no statistically significant difference in age between the mild and severe groups(P>0.05).The serum 25(OH)D value of 49 children with mild pneumonia was(22.26±6.74)ng/m L;The serum 25(OH)D value of 51 children with severe pneumonia was(12.62±6.33)ng/m L.There was a statistically significant difference in vitamin D levels between the two groups(t=7.377,P<0.05).The Spearman rank correlation results showed a negative correlation between vitamin D levels in children and the severity of pneumonia(r=-0.628,P<0.05).Conclusion:1.This study indicates that Tibetan children with pneumonia have a deficiency in vitamin D,and the rate of vitamin D deficiency and deficiency is higher than that of normal children in China.There is a certain correlation between the severity of pneumonia in children and the level of vitamin D.The lower the level of vitamin D,the more severe the severity of pneumonia.2.Although Tibet has high altitude and long sunshine,there is still a lack of vitamin D,which is still related to factors such as the child’s living area,whether the mother supplements vitamin D during the perinatal period,the feeding method of the child within 6months after birth,the daily milk amount before the age of 2,and whether fortified foods are supplemented between 6 months and 2 years old. |
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