Clinical Efficacy Of Tranquilizing And Stabilizing The Heart Soup In The Treatment Of Ventricular Preterm Contraction(Phlegm And Fire Disturbing The Heart) With Insomnia

Objective: To investigate the clinical efficacy and safety of Anshen Wenxin decoction Plus and Minus in the treatment of ventricular preterm contraction with insomnia by observing the clinical efficacy and safety of Anshen Wenxin decoction Plus and Minus in ventricular preterm contraction(phlegm and fire disturbing the heart type)with insomnia.Method: In this study,outpatients of the Department of Cardiovascular Diseases I of the First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine who met the inclusion criteria(December 2021 to December 2022)were used as the data source,and a total of 70 patients with ventricular prophase contraction(phlegm and fire disturbing the heart type)with insomnia were collected and randomly divided into 35 cases each in the control group and treatment group,with one case falling off in the control group and two cases falling off in the treatment group during the treatment.The control group was given metoprolol succinate extended-release tablets(Betaxolol)combined with eszopiclone,while the treatment group was given Anshen Wenxin decoction Plus and Minus for a period of 4 weeks.The TCM evidence score,24-hour ambulatory ECG frequency of ventricular premature,QTc,Tp-e/QT,Pittsburgh Sleep Quality Index scale(PSQI),and Quality of Survival Rating Scale(WHOQOL-BREF)were observed and recorded in both groups before and after treatment,and the safety and occurrence of adverse effects were evaluated.Results:1.The difference was statistically significant(P < 0.05);the treatment group was better than the control group in reducing the total score of TCM symptoms after treatment,and the difference was statistically significant(P <0.05);the total effective rate of improvement of TCM symptoms in the treatment group was 90.9%,and the total effective rate in the control group was 64.7%,and the difference between the two groups was statistically significant(P < 0.05).The difference between the two groups was statistically significant(P < 0.05),and the total effective rate of the treatment group was better than that of the control group.2.24 hours total ventricular early and efficacy: Both groups could reduce the total ventricular early(P < 0.05),and the treatment group was better than the control group in reducing the total ventricular early,the difference was statistically significant(P < 0.05).The total effective rate was87.9% in the treatment group and 67.6% in the control group,and the difference was statistically significant(P < 0.05).The total effective rate of the treatment group was better than the control group.3.QTc and Tp-e/QT: There was no significant difference between QTc and Tp-e/QT before treatment(P > 0.05).After treatment,there was no significant difference in QTc and Tp-e/QT between the treatment group and the control group(P > 0.05),but both groups were improved in intra-group comparison,and the difference was statistically significant(P < 0.05).4.PSQI score: Both groups could reduce the PSQI score of patients(P <0.05),the treatment group was better than the control group in reducing the PSQI score of patients,the difference was statistically significant(P < 0.05).5.Quality of Survival Rating Scale scores: there was a statistically significant difference between the two groups after treatment in the physical and psychological domains compared(P < 0.05),while there was no statistically significant difference in the social relations and environmental domains compared(P > 0.05).6.There was no statistically significant difference between the two groups in the pre and post changes in safety indicators such as liver and kidney function(P > 0.05),and no adverse events occurred during the treatment period.Conclusion: The treatment of phlegm-fire disturbed ventricular premature contraction with insomnia with Anshen Wenxin decoction Plus and Minus has remarkable efficacy,effectively improving the clinical symptoms and signs of patients,significantly reducing the number of ventricular premature,decreasing the severity of PVC,improving sleep quality,and enhancing the quality of life of patients with high safety.