Expression And Clinical Significance Of LKB1,INPP4B And AKT In Cervical Adenocarcinoma

Objective:In this study,the expression of LKB1,INPP4B and AKT in cervical adenocarcinoma tissues was observed at the histological level,so as to explore the relationship between the expressions of LKB1,INPP4B and AKT,the clinicopathological factors and survival prognosis of patients with cervical adenocarcinoma.The correlation among expression of LKB1,INPP4B and AKT was analyzed to provide new ideas for the diagnosis,prognosis and later treatment of cervical adenocarcinoma.Method:From January 1,2016 to December31,2021,100 patients diagnosed as cervical adenocarcinoma by surgical resection and pathologist were collected in our hospital,with complete follow-up data and 30 specimens of chronic cervicitis.The expressions of LKB1,INPP4B and AKT in the above tissues were detected by immunohistochemical staining,and the data were analyzed by statistical software.Results:1.The expression rates of LKB1,INPP4B and AKT were 40%,38% and 68% in cervical adenocarcinoma tissue,and 83%,77% and 0% in chronic cervicitis tissue,respectively,and the differences were statistically significant(P<0.05).2.The expressions of LKB1,INPP4B and AKT were correlated with tumor involvement of cervical canal,lymph node metastasis,tumor invasion depth,distant metastasis and high FIGO stage,with statistical significance(P<0.05).3.LKB1 was positively correlated with the expression of INPP4B,LKB1 was negatively correlated with the expression of AKT,and AKT was negatively correlated with the expression of INPP4B(all P <0.05).4.Low expression of LKB1,low expression of INPP4B,high expression of AKT,distant metastasis and FIGO stage are independent prognostic risk factors for cervical adenocarcinoma patients.Conclusion:1.The low expression of LKB1 and INPP4B and the high expression of AKT may promote the invasion and metastasis of cervical adenocarcinoma.2.The inhibitory effect of LKB1 on invasion and metastasis of cervical adenocarcinoma may be realized through INPP4B and AKT.3.Combined detection of LKB1,INPP4B and AKT can predict the survival and prognosis of patients with cervical adenocarcinoma.