Clinical Observation Of Self-Made Xiaoying Decoction Based On Data Mining In The Treatment Of Thyroid Nodules With Qi Stagnation And Phlegm Obstruction

ObjectiveThrough data mining,self-designed Xiaoyin Decoction was used to treat patients with Qi-stagnation and phlegm-blocking thyroid nodule.According to the improvement of clinical symptoms,signs and imaging,objective evaluation was made on the efficacy of self-designed Xiaoyin decoction,which provided scientific and evidence-based support for clinical TCM syndrome differentiation treatment of thyroid nodule.Method1.Data miningIn this study,data mining was carried out on the literatures related to TCM treatment of thyroid nodule included in CNKI database from 2001 to 2021,and keyword cluster analysis was carried out by citespace,a bibliometrics software,to predict the research hotspots of thyroid nodule in recent years.The"Prescription management" module in the "Platform Management System",an assisting platform for traditional Chinese medicine inheritance,was selected to input the prescriptions for treating thyroid nodule with qi stagnation and phlegm blockage selected from the literature database one by one.According to the analysis results,self-designed Xiaogall decoction was prepared according to the expert experience.2.Clinical observationCase data of patients treated in the Second outpatient Department of the First Affiliated Hospital of Heilongj iang University of Chinese Medicine from March 2022 to September 2022 were collected,and 60 patients with Qi-stagnation and phlegm-blocking thyroid nodules meeting the inclusion criteria,and 30 patients in each control group and observation group were screened.The control group was given Wuhai Gall tumor pill,and the observation group was given self-designed gall elimination decoction based on the data mining results and the clinical experience of the tutor.The two groups were treated for three courses of treatment.The TCM syndrome scores and maximum nodule diameters of the two groups at two nodes were recorded respectively before and after the treatment course,and SPSS software was used for statistical analysis.ResultTwo patients were shed during treatment,and data of 58 cases were obtained,including 29 cases in the control group and 29 cases in the observation group.1.Total scores of TCM syndromesBefore treatment,there was no significant difference in the total score of TCM syndrome between the two groups(p>0.05).After treatment,the total score of TCM syndrome in the observation group was 9.14±0.53 before treatment and 5.21±0.64 after treatment,with significant difference(P<0.05).The total score of TCM syndrome in control group was 8.83±0.45 before treatment and 7.72±0.69 after treatment,the difference was significant(P<0.05).After treatment,the difference between the two groups was statistically significant(P<0.05).Both the control group and the observation group were improved after treatment,but the observation group had a more significant effect.2.Maximum nodule diameterBefore treatment,the maximum nodule diameter of the observation group was 1.84±0.12(cm),while that of the control group was 1.85±0.12(cm).Compared between the two groups,p>0,05,the difference was not statistically significant and was comparable.After three courses of intervention treatment,the maximum nodule diameter of the observation group was 1.24±0.19,compared with before treatment,p<0.05,which had a significant difference,and the observation group had a significant effect.The maximum nodule diameter in the control group was 1.48±0.17,compared with before treatment,p<0.05,indicating that the treatment effect in the control group was obvious.After treatment,the difference between the two groups was statistically significant(p<0.05).The curative effect of observation group was better than control group.3.Clinical effectTCM syndrome score:in the observation group,there were 4 cases of ineffective treatment(13.79%),19 cases of effective treatment(65.52%),6 cases of obvious effect(20.69%),0 cases of recovery(0.00%),the total effective rate of 86.21%;In the control group,13 cases were ineffective(44.83%),16 cases were effective(55.17%),0 cases were effective(0.00%),0 cases were cured(0.00%),and the total effective rate was 55.17%.P<0.05,the difference was statistically significant,the observation group was significantly better than the control group.Maximum nodule diameter:The reduction of maximum nodule diameter in the observation group was ineffective in 5 cases(17.24%),effective in 22 cases(75.86%),effective in 2 cases(6.90%),cured in 0 cases(0.00%),and the total effective rate was 82.76%.The maximum reduction degree of nodule diameter in the control group was as follows:7 cases were ineffective(24.14%),22 cases were effective(75.86%),0 cases were effective(0.00%),0 cases were cured(0.00%),and the total effective rate was 7 5.86%,P<0.05,the difference was statistically significant.The effect of nodule reduction in the observation group was generally better than that in the control group.4.Security indicatorsNo adverse reactions occurred in both groups during the treatment,and the safety level was level 1.Conclusion1.Self-designed Xiaoying decoction is effective in the treatment of Qi-stagnation and phlegm-blocking thyroid nodule,which can significantly improve the symptoms of neck distension,chest dullness,emotional depression,nausea and retching,phlegm tolerance,dyspnea and other symptoms,effectively reduce the diameter of thyroid nodule,and has no obvious adverse reactions,which is worthy of clinical application and promotion.2.The clinical efficacy of self-designed Xiaoyin Decoction confirmed that Citespace and traditional Chinese medicine inheritance assistance platform promote the development of traditional Chinese medicine,and demonstrated the reliability of the excavation results of the thyroid nodule formula of Qi stagnation and phlegm-blocking.