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Clinical Observation Of Zhongjing Quyu Lishui Formula Plus And Minus Combined With Intraventricular Injection Of Leizumab In The Treatment Of Retinal Vein Obstruction Macular Edema

Posted on:2024-09-26Degree:MasterType:Thesis
Country:ChinaCandidate:X X LiuFull Text:PDF
GTID:2544307085456304Subject:Traditional Chinese Medicine
Abstract/Summary:PDF Full Text Request
Obj ective:By observing the effects of modified traditional Chinese medicine Zhongjing Quyu Lishui Formula combined with Leizumab intraglobular injection on the treatment of phlegm stasis accumulation,spleen deficiency and dampness type retinal vein occlusion macular edema,as well as the best corrected visual acuity(BCVA),macular fovea thickness(CMT),and subjective symptoms of patients with Leizumab injection alone,the therapeutic differences between the two methods were objectively evaluated.The therapeutic effects of Zhongjing Quyu Lishui combined with Leizumab intraglobular injection on phlegm stasis accumulation were observed The therapeutic effect of spleen deficiency dampness type retinal vein occlusion macular edema provides other diagnostic and therapeutic directions for the treatment of retinal vein occlusion macular edema.Methods:This study included 66 patients(66 eyes)who were treated in the ophthalmology ward of the First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine from November 20,2021 to November 20,2022,all of whom met the inclusion criteria.All enrolled patients were diagnosed with phlegm and blood stasis,spleen deficiency and dampness type retinal vein occlusion and macular edema with the assistance of the same Chinese medicine doctor with years of clinical experience in traditional Chinese medicine.66 patients were randomly divided into a control group and a treatment group,The control group was treated with intraglobular injection of Leizumab;The treatment group was treated with oral Chinese medicine Zhongjing Quyu Lishui Fang modified and combined with intraglobular injection of Leizumab.The specific methods are as follows:Control group:1+PRN intraventricular injection of leizumab was used for 3 months.Treatment group:Oral Zhongj ing Quyu Lishui prescription plus or minus combined with Leizumab intraventricular injection therapy,a total of 3 months.The oral method of TCM was Zhongj ing Quyu Lishui Prescription in small package,3 00ml per dose,divided into morning and evening,7 days a week,for 12 weeks.Intraventricular injection of leizumab was the same as control group.BCVA,CMT,fundus conditions and TCM symptom and sign scores of the treatment group and the control group were observed and compared before treatment,1 month after treatment,2 months after treatment and 3 months after treatment.Clinical effective rates of the two groups were compared before and after treatment.Results:1.Before treatment,statistical analysis was conducted on the basic situation,BC VA,CMT,fundus bleeding,and traditional Chinese medicine syndrome scores of the two groups of patients(P>0.05),indicat ing comparability.2.After 3 months of treatment,the BCVA of both groups of patients increased(P<0.01),and the treatment group was better than the control group(P<0.05).3.After 3 months of treatment,the CMT of both groups of patients decreased(P<0.01),and the treatment group was better than the control group(P<0.05).4.After 3 months of treatment,the fundus condition of both groups of patients improved relatively,and the treatment group was better than the control group(P<0.05).5.After 3 months of treatment,the TCM syndrome scores of both groups of patients decreased(P<0.01),and the treatment group was better than the control group(P<0.05).Conclusions:1.Both simple intrabulbar injection of Leizumab and oral administration of traditional Chinese medicine Zhongjing Quyu Lishui Formula combined with intrabulbar injection of Leizumab have clinical efficacy in treating retinal vein occlusion and macular edema caused by phlegm and blood stasis,spleen deficiency and dampness.2.Both options can increase BCVA,reduce CMT,improve FFA,and reduce clinical syndrome scores in traditional Chinese medicine.In terms of effectiveness,the combination of oral Chinese herbal medicine Zhongj ing Quyu Lishui Fang and intrabulbar injection of Leizumab is significantly better than simple intrabulbar injection of Leizumab.
Keywords/Search Tags:Retinal vein occlusion, Macular edema, Phlegm-stasis interjunction,spleen deficiency and dampness-sheng type, Leizumab, Zhongjing dispelling blood stasis and lishui prescription
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