Effect Of Buyang Huanwu Decoction Combined With 577nm Micropulse Laser On Macular Edema Of Qi Deficiency Blood Stasis Syndrome Retinal Vein Occlusion(Non-ischemic)

Purpose:The best corrected visual acuity(BCVA),central macular thickness(CMT),retinal cycle time(RCT),and retinal hemorrhage absorption were observed before and after treatment,and compared with the group treated with 577 nm micropulse laser alone.Evaluated the clinical efficacy of Buyang Huanwu Decoction combined with 577 nm micropulse laser on macular edema of Qi deficiency blood stasis syndrome retinal vein obstruction(non-ischemic)systematically,to provide a scientific basis for clinical decision.Method:From January 2021 to December 2021,the 64 patients RVO-ME(non-ischemic)with Qi deficiency blood stasis were treated in the People’s Hospital Affiliated to Fujian University of Traditional Chinese Medicine.According to the time of visit,the patients were divided into two group: 577 nm micropulse laser group(control group)(32 eyes)and Buyang Huanwu decoction combined with 577 nm micropulse laser(treatment group)(32 eyes).The treatment group was treated with Buyang Huanwu Decoction combined with 577 nm micropulse,the control group was treated with simple 577 nm micropulse laser.By comparing BCVA,CMT,RCT and retinal hemorrhage absorption of the two groups before and after treatment at 1month,2month,3month,and various time point,and compared the overall efficacy.Result:1.Comparison before treatment: There was no statistically significant differences in age,gender,BCVA,CMT,RCT and retinal hemorrhage between the two groups(P>0.05).2.Comparison of BCVA after treatment: The BCVA of both groups improved at 1month,2 months and 3 months after treatment compared with that before treatment,and the difference was statistically significant(F=60.201,P=0.000<0.05),and there was a statistically significant difference in the efficacy of different treatment regimens on improving BCVA between the two groups(F=4.558,P=0.037<0.05);meanwhile,the interaction of treatment regimen and treatment course had a statistically significant difference on BCVA between the two groups,there was a statistically significant difference in the effect of the interaction of treatment regimen and course on BCVA,indicating that there was a significant difference in the overall trend of BCVA improvement with the progression of the treatment course(F=6.975,P=0.000<0.05),and the BCVA of the treatment group was better than that of the control group at 1,2,and 3 months after treatment,with statistically significant differences.(P=0.000,P=0.000 P=0.000,<0.05)3.Comparison of CMT after treatment: the CMT in both groups decreased at 1 month,2months and 3 months after treatment compared with that before treatment,and the difference was statistically significant(F=312.608,P=0.000<0.05),and there was a statistically significant difference in the efficacy of different treatment regimens on reducing CMT between the two groups(F=6.267,P=0.015<0.05);meanwhile,the interaction of treatment regimen and treatment course had a statistically significant difference on CMT between the two groups,there was a statistically significant difference in the effect of the interaction of treatment regimen and course on CMT,indicating that there was a significant difference in the overall trend of CMT decrease with the progression of the treatment course(F=11.069,P=0.000<0.05),and CMT in the treatment group was lower than that in the control group,and the differences were statistically significant(P=0.000,P=0.000,P=0.000,<0.05).4.Comparison of retinal hemorrhage absorption after treatment: the overall effective rate of retinal hemorrhage absorption in the control group was 76.67%,and the overall effective rate of retinal hemorrhage absorption in the treatment group was 86.67%,and the difference in the efficacy of different treatment regimens in promoting retinal hemorrhage absorption was statistically significant(Z=-2.033,P=0.042<0.05).5.Comparison of RCT after treatment: the RCT in both groups shortened after treatment compared with that before treatment,and there was a statistically significant difference in the efficacy of different treatment regimens for shortening RCT between the two groups.(Z=9.414,P=0.002<0.05)6.The overall efficiency after treatment was 83.33% in the control group and 90.00% in the treatment group 3 months after treatment,and the different treatment regimens of the two groups were effective in treating RVO-ME and the difference in the efficacy of different treatment regimens for RVO-ME was statistically significant(Z=-2.033,P=0.035<0.05)Conclusion:1.The treatment efficacy of 577 nm micropulse laser in RVO-ME(non-ischemic)with Qi deficiency blood stasis,mainly in terms of improvement of BCVA,shortening of RCT,absorption of retinal hemorrhage,and fading of ME.2.Compared with the treatment of 577 nm micropulse laser alone,the treatment of Buyang Huanwu decoction combined with 577 nm micropulse laser was more effective in RVO-ME(non-ischemic)with Qi deficiency blood stasis,by the latter’s better ability to improve BCVA,reduce CMT,shorten RCT,and promote the absorption of retinal hemorrhage and the regression of macular edema.moreover,it can improve the retinal venous microcirculatory stasis in the early stage of incomplete occlusion,promote the recovery of retinal blood supply,and then improve the local ischemia and hypoxia,reduce retinal small vessel leakage,further reduce macular edema,and finally achieve the goal of improving visual acuity,protecting visual function,and avoiding further aggravation of RVO.