| Objective:Study 1:Data mining technology was used to retrospectively study the outpatient medical records of EH patients in order to summarize the characteristics of EH and medication rules,so as to provide some reference for clinical practice.Study 2:Through the method of data mining,the law of internal administration medication in vertigo medical records of modern Chinese history was analyzed to explore the medication experience of physicians of modern Chinese history in the treatment of vertigo.Methods:Study 1:The medical records of 128 patients diagnosed with primary hypertension during their visits to the experts’ clinic of the Second Department of Cardiovascular Disease in the First Affiliated Hospital of Heilongjiang University of Chinese Medicine from October 2020 to April 2022 were collected and organized.The data mining technology was used to analyze the information of patients’ sex,age,precipitating factor,family history,initial blood pressure measurement,tongue and pulse,and oral prescription,and to analyze the morbidity characteristics and medication rules of EH patients in the outpatient department from multiple views.Study 2:The vertigo medical records of modern Chinese history in the part of "Medical Records" in the Chinese Medical Dictionary and the library collection of Heilongjiang University of Chinese Medicine were collected,and the medication information was organized and standardized.The data mining technology was used to analyze the four qi,five flavors,meridian tropism,and frequency of use of the oral prescriptions,as well as the Chinese medicine association rule analysis and clustering analysis,to obtain the medication rules of physicians of modern Chinese history in the treatment of vertigo.Result:Study 1:1.General situation:(1)Sex and age:73 females and 55 males are found in 128 patients with essential hypertension,and the number of patients aged from 60 to 69 years old is the largest.(2)Cause of disease:Most of the 128 patients had no obvious cause,and the second most obvious cause was fatigue and unreasonable dietary structure.(3)Family history:Among the 128 patients included in the study,45 cases had a family history of hypertension,24 cases had a family history of diabetes,and 21 cases had a family history of coronary heart disease.(4)Initial blood pressure measurement:The results of initial blood pressure measurement showed that among 128 patients,there were 50 cases of grade 1 hypertension,36 cases of grade 2 hypertension,23 cases of grade 3hypertension and 19 cases of isolated systolic hypertension.2.Tongue and pulse conditions:A total of 10 tongue qualities were recorded in this study,and the most frequently occurring ones were red tongue,pale red tongue and dark tongue;There were eight kinds of tongue coating,and the ones with thin white coating,thin yellow coating,and white greasy coating appeared more frequently.There were 12 kinds of pulse manifestations,and the deep thready pulse,the thready pulse and the wiry thready pulse were the most frequent ones.3.Traditional Chinese medicine attribute:(1)Analysis of four qi:the most frequent ones were cold,mild and warm.(2)Five-flavor analysis:The most frequently occurring ones were sweet,bitter and pungent.(3)Analysis of meridian tropism:the liver meridian,lung meridian,and spleen meridian appeared more frequently.(4)Efficacy analysis:The most frequently-appearing herbs were tonifying deficiency,heat-clearing and exterior-relieving herbs.4.Analysis of Chinese medicines frequency:A total of 159 Chinese medicines were involved in the 128 oral prescriptions for outpatient medical records,and the total use frequency of Chinese medicines was 2473 times.There are 60 kinds of traditional Chinese medicines used more than 10 times.After licorice is removed,the top ten high-frequency drugs are Scutellaria baicalensis,Pinellia ternata,Bupleurum,Chrysanthemum,Oyster,Os Draconis,Chuanxiong,Radix Paeoniae Alba,Poria and Ramulus Cinnamomi in turn.5.Analysis of association rules:(1)Analysis of association rules of Chinese medicines: Two Chinese medicines association combinations were summarized,which we Analysis of association rules of Chinese medicines re Radix Paeoniae Alba-Radix Bupleuri-Rhizoma Pinelliae-Ramulus Cinnamomi,and Os Draconis-Concha Ostreae-Radix Scutellariae-Rhizoma Pinelliae respectively..(2)Syndrome-medicine relationship in outpatient department: In addition to the main symptom of dizziness,Radix Scutellariae was closely related to the symptoms of upset.Poria cocus was closely related to insomnia symptoms.Semen Cassiae,Flos Chrysanthemi,Radix Scutellariae,Radix Bupleuri,and Rhizoma Pinelliae were closely related to ocular distension symptoms.Evodia rutaecarpa,chrysanthemum and scutellaria baicalensis are closely related to headache.6.Clustering analysis of Chinese medicines:five core combinations w ere obtained:The first type is Concha Ostreae-Os Draconis-Radix Paeo-n iae Alba-Ramulus Cinnamomi-Radix et Rhizoma Rhei-Radix Bupleuri-Rhi zoma Pinelliae-Poria-Bulbus Lilii;The second type is Semen Ziziphi S-pi nosae-Radix et Rhizoma Polygalae-Poria cocos-Caulis Polygoni Multifl-o ri;The third type is rhizoma ligustici chuanxiong-saviae miltiorrhizae r-a dix;The fourth type is Achyranthis Radix-Eucommiae Cortex-Rhizoma Ga strodiae-Ramulus Uncariae cum Uncis-Concha Haliotidis-Fructus Garde-ni ae;The fifth type is flos chrysanthemi-semen cassiae-fructus evodiae-pru nellae spica.Study 2:1.Traditional Chinese medicine attribute:(1)Analysis of four qi:the most frequent ones were cold,warm and mild.(2)Five-flavor analysis:The most frequently occurring ones were swe-et,bitter and pungent.(3)Analysis of meridian tropism:the liver meridian,lung meridian,and spleen meridian appeared more frequently.The results of four qi,five-flavor and meridian tropisms were similar to those in clinical outpatient medical records.2.Analysis of Chinese medicines frequency:A total of 257 Chinese medicines were covered in 146 oral prescriptions for vertigo medical records of modern Chinese history,with the total use frequency of 1600 Chinese medicines.A total of 17 Chinese medicinal materials were used more than 20 times,and the high-frequency Chinese medicines in the top 10 were Rhizoma Pinelliae,Concha Haliot-idis,Radix Paeoniae Alba,Flos Chrysanthem-i,Poria,Fructus Tribuli,Radix Angelicae Sinensis,Poria cocos,Radix Rehm-anniae,and Folium Mori in se-quence.3.Analysis of association rules of Chinese medicines:Two Chinese medicines association combinations were summarized,which were Rhizom-a Pinelliae-Pericarpium Citri Reticulatae-Poria,and Flos Chrysanthemi-C oncha Haliotidis-Radix Polygoni Multiflori-Folium Mori.4.Clustering analysis of Chinese medicines:Three core combinations were obtained:The first one was Concha Haliotidis,Flos Chrysanthemi,Fo-lium Mori,Cortex Moutan,Ramulus Uncariae cum Uncis,and Rhizoma Ga-strodiae;The second type is rhizoma pinelliae-pericarpium citri tangerinae-cauli bambusae in taenia-Poria-fructus tribuli;The third type was Radi-x Rehmanniae-Radix Glycyrrhizae-Radix Paeoniae Alba-Radix Angelicae Sinensis-Rhizoma Atractylodis Macrocephalae-Poria cocos-Concha Ostreae.Conclusion:Study 1:1.There are more females than males in the outpatient EH patients,and the age distribution is mainly concentrated in the 50–69 years old.Nearly half of the patients have a family history of hypertension,suggesting that there is a significant familial aggregation of EH.The results of the study suggest that work-rest disorders and poor diet are also closely related to the occurrence of EH.In the outpatient medical records,the red tongue is dominant in tongue quality,and the thin and white coating is dominant in tongue;the deep and thready pulse is dominant in pulse manifestation.2.Outpatient experts mostly believe that the main location of vertigo was in heart and often related to the lung,spleen,heart,stomach and other zang-fu organs.The four qi Chinese medicines used are mainly cold,mild and warm in nature,and mainly contain sweet,bitter and pungent herbs.They are mainly of tonic,heat-clearing and wind-dispelling herbs.3.The efficacies of 10 high-frequency Chinese medicines for the tre-atment of EH in outpatient medical records were mainly as follows:ton-ifying qi and blood,drying dampness and promoting urination,pacifying liver and subduing yang.4.The related combination of the two Chinese medicines has the ef-fects of regulating qi and blood,regulating yingwei,inhibiting liver and subduing yang,resolving phlegm and clearing heat,respectively.5.The core combinations of the five clusters had the effects of soothing liver and nourishing liver,nourishing and tranquilizing mind,moving qi and activating blood,nourishing yin and suppressing yang,and clearing liver and purging fire,respectively.Study 2:1.Physicians in modern Chinese history mostly believed that the location of vertigo was mainly in the liver and lung,which was closely related to the spleen,heart,stomach,kidney and other zang-fu organs.The traditional Chinese medicines used were mainly cold,warm and neutral herbs,with the flav ors of sweet,bitter and pungent.The four-qi,five-flavor and meridian tropism of the traditional Chinese medicines used were similar to the medical records in clinical outpatient departments.However,the differences in details reflected the medication characteristics of liver and lung being treated in the same way,cold and warm being combined,bitter and acrid drugs with descending methods.2.In medical records vertigo medical records of modern Chinese his-tory,the efficacy of 10 high-frequency Chinese medicines for the treatm e-nt of vertigo is mainly manifested as drying dampness and resolving phlegm,dispelling wind and clearing heat,pacifying and softening liver.3.The related combination of the two Chinese medicines has the effects of drying dampness,resolving phlegm,reducing adverse flow,pacifying the liver,removing wind and nourishing blood,respectively.4.The core combinations of the three clusters had the effects of pacifying liver and clearing liver,resolving phlegm and removing wind,nou rishing yin and nourishing blood,respectively. |
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