Retrospective Analysis Of TCM Syndrome Distribution In 216 Patients With Chronic Heart Failure

Objective:To observe the distribution of TCM syndrome types in patients with chronic heart failure in our hospital,study the differences of related physical and chemical indexes in the distribution of syndrome types,and find the risk factors affecting the distribution of syndrome types.Methods:Medical records of 216 patients diagnosed with chronic heart failure admitted to the Second Department of Cardiovascular Disease,the First Affiliated Hospital of Heilongjiang University of Chinese Medicine from September 2019 to September 2022 were collected.The general information,course of disease,cardiac function grading,combined with other diseases and other conditions of patients were statistically described.SPSS 26.0 statistical software was used to analyze the correlation between TCM syndrome types and related physicochemical indexes of chronic heart failure.Results:1.The distribution of TCM syndrome types in 216 patients with chronic heart failure was:Qi and Yin deficiency and blood stasis syndrome>Qi deficiency and blood stasis syndrome>Qi deficiency and blood stasis syndrome with phlegm and drink syndrome>Qi deficiency and blood stasis syndrome with phlegm and drink syndrome>Yang deficiency and blood stasis syndrome>Qi deficiency and blood stasis syndrome>Qi deficiency and blood stasis syndrome>Qi and Yin deficiency and blood stasis syndrome with phlegm and drink syndrome;2.There were 107 males and 109 females,and there was no significant difference in the distribution of syndrome types between genders(P>0.05).3.The minimum age is 24,the maximum age is 97,and the average age is 71.61.The largest number of patients between 71 and 80 years old:4.The longest course of disease was less than 5 years,the shortest course was 9 months,the oldest was 51 years and the average course of disease was 10.36 years.5.The number of patients with chronic heart failure grade Ⅲ was the largest;6.The top four common comorbidities were hypertension(61.6%),coronary heart disease(56.0%),cerebrovascular disease(53.7%),and hyperlipidemia(45.4%);7.The top ten basic prescriptions used in the first clinic from high to low were Shengmai SAN,Yangxin Dingchuan decoction,Xuefu Zhuyu decoction,Zhenwu decoction,Tingli Dazao Xiefei decoction,Lingguizhugan decoction,Guipi decoction,Baoyuan decoction,Shenfu decoction and Siwu decoction.8.The top ten Chinese medicine using frequency from high to low were Glycyrrhiza radix,Radix codonopsis,Angelica sinensis,Astragalus membra-naceus,Ophiopogonis ophiopogonis,Schisandrae chinensis,Poria coporia,Atractylodes rhizoma,Ligusticum chuangxiong and peach kernel.9.There were significant differences in the distribution of LVEF among different syndromes(P<0.05),but no significant differences in the distri-bution of LVFS,LVEDD,LVESD,IVSD and LVPWD(P>0.05).10.There were no significant differences in MPV,ALT,AST,UA,CK-MB,Hcy,FBG,TG,TC,LDL,K+,Na+,Cl-among the TCM syndrome types(P>0.05).There were significant differences in NT-proBNP,HGB,hsCRP,Cr and HDL among the TCM syndrome types(P<0.05).11.LVEF is a risk factor for Yang qi deficiency and blood stasis syndrome.HGB was a risk factor for Yang qi deficiency and blood stasis,qi and Yin deficiency and blood stasis combined with phlegm deficiency,Yang deficiency and blood stasis combined with phlegm deficiency.hs-CRP is a risk factor for Yang deficiency and blood stasis combined with phlegm deficiency syndrome.NT-proBNP is a risk factor for qi deficiency,blood stasis and phlegm deficiency syndrome,qi and Yin deficiency,blood stasis and phlegm deficiency syndrome,Yang deficiency,blood stasis and phlegm deficiency syndrome.Cr is a risk factor for qi deficiency and blood stasis combined with phlegm deficiency syndrome and Yang deficiency and blood stasis combined with phlegm deficiency syndrome.HDL is a risk factor for qi deficiency,blood stasis and phlegm deficiency syndrome and Yang deficiency,blood stasis and phlegm deficiency syndrome.Conclusion:1.The results of this study showed that the distribution of TCM syndrome types in patients with chronic heart failure was Qi and Yin deficiency and blood stasis syndrome>Qi deficiency and blood stasis syndrome>Qi deficiency and blood stasis syndrome with phlegm and drink syndrome>Qi deficiency and blood stasis syndrome with phlegm and drink syndrome>Yang deficiency and blood stasis syndrome>Qi deficiency and blood stasis syndrome>Qi deficiency and blood stasis syndrome>Qi and Yin deficiency and blood stasis syndrome with phlegm and drink syndrome.2.There are significant differences in the distribution of LVEF,HGB,creatinine,HDL,NT-proBNP and hs-CRP among different TCM syndroms of chronic heart failure.3.LVEF,HGB,creatinine,HDL,NT-proBNP,hs-CRP were the risk factors affecting the distribution of TCM syndrome types.