| Objective In this study,oral hydroxychloroquine sulfate tablets combined with external hyaluronic acid repair biofilm were used to treat mild and moderate rosacea,and the clinical efficacy,safety,physiological indexes of skin barrier function and changes of serum inflammatory factors LL-37,TNF-α,IL-6 and IL-17 A were observed to explore the possible mechanism of hydroxychloroquine sulfate in the treatment of rosacea.To provide a more sufficient reference for the clinical use of hydroxychloroquine sulfate and skin barrier repair agent in the treatment of rosacea.Methods According to the inclusion and exclusion criteria,90 patients meeting the diagnostic criteria for mild and moderate rosacea were collected from the dermatology department of Shenyang Seventh People’s Hospital and randomly divided into three groups.Hyaluronic acid group(30 cases)was treated with Winona hyaluronic acid repair biofilm for external use,once in the morning and once in the evening,for 8weeks;Hydroxychloroquine sulfate group(30 cases)was given oral hydroxychloroquine sulfate tablets,0.2g(2 tablets)in the morning and evening for 8weeks;Combined group(30 cases)was given Winona hyaluronic acid repair biofilm for external use,once in the morning and once in the evening,and hydroxychloroquine sulfate tablets for oral use,0.2g(2 tablets)in the evening and once in the evening,for 8weeks.Physiological indexes of skin barrier function(TEWL,SCH,skin p H)were detected and recorded in all patients before and 8 weeks after treatment;clinical symptom scores were assessed and recorded in all patients before and 8 weeks after treatment;serum levels of inflammatory factors LL-37,TNF-α,IL-6,and IL-17 A were detected in all patients before and 8 weeks after treatment;serum levels of inflammatory factors LL-37,TNF-α,IL-6,and IL-17 A were detected in healthy individuals;SPSS26.0 statistical software was used for analysis.Results1.Clinical symptom scores,after 8 weeks of treatment,the hyaluronic acid group,hydroxychloroquine sulfate group,and the combination group were 10.10 ± 1.04,8.30± 1.70,6.10 ± 1.59;For pre-and post-treatment comparisons among the three groups,significant differences(P<0.05);For pairwise comparisons among the three groups after treatment,significant differences(P<0.05)were observed between the combination group and the hyaluronic acid group or hydroxychloroquine sulfate group;hydroxychloroquine sulfate group versus the hyaluronic acid group(P< 0.05).2.After 8 weeks of treatment,the response rate was 40.00% in the hyaluronic acid group,56.67% in the hydroxychloroquine sulfate group,and 73.33% in the combination group;For pairwise comparisons among the three groups after treatment,significant differences(P < 0.05)were observed between the combination group and the hyaluronic acid group or hydroxychloroquine sulfate group;hydroxychloroquine sulfate group versus the hyaluronic acid group(P < 0.05).3.The physiological indicators of skin barrier,TEWL and SCH values after 8weeks of treatment,were compared before and after treatment among the three groups.The difference between the combination group and the hyaluronic acid group was statistically significant(P<0.05),while the difference between the hydroxychloroquine sulfate group was not statistically significant(P>0.05);There was no statistically significant difference in p H values among the three groups(P>0.05);After treatment,there was a pairwise comparison between the three groups.The differences in TEWL and SCH values among the three groups were statistically significant(P<0.05),while there was no statistically significant difference in p H values among the three groups(P>0.05).4.The levels of serum inflammatory factors were significantly different between the case groups and the healthy group(P<0.05);After 8 weeks of treatment,there was no statistically significant difference in LL-37,IL-6,and IL-17 A among the three groups of patients(P>0.05);Inflammatory factor TNF-α Compared,the difference was statistically significant(P<0.05);There was no statistically significant difference in LL-37,IL-6,and IL-17 A before and after treatment among the three groups(P>0.05);Inflammatory factor TNF-α Compared with the hyaluronic acid group,the difference was not statistically significant(P>0.05);The difference between the hydroxychloroquine sulfate group and the combination group was statistically significant(P<0.05).Conclusions1.Hyaluronic acid repair biofilm can significantly improve the SCH of patients with mild to moderate rosacea,reduce TEWL,and improve the damaged skin barrier function of patients2.Hyaluronic acid repair biofilm can significantly improve the SCH of patients with mild to moderate rosacea,reduce TEWL,and improve the damaged skin barrier function of patients3.Oral administration of hydroxychloroquine sulfate tablets can reduce the serum level of inflammatory factor TNF-α in patients with rosacea. |
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