Clinical Observation Of Introducing Compound Glycyrrhizin Injection By Pneumatic Spray Instrument And Hydroxychloroquine Oral On Skin Barrier Function With Rosacea Patients

Objective:Erythematous telangiectasia rosacea is a chronic inflammatory facial skin disease which is difficult to treat clinically.It has impaired skin barrier function and is prone to recurrence.According to the characteristics of the disease,introducing Compound Glycyrrhizin Injection by pneumatic spray instrument and Hydroxychloroquine oral was used to treat the disease.The changes of skin barrier function were observed clinically,which provided reliable basis for clinical application and promotion.Methods: According to the inclusion criteria,exclusion criteria and rejection criteria,59 patients with erythematous telangiectasia rosacea were selected,which from the Department of Dermatology,Affiliated Hospital of Guilin Medical College,from January2018 to October 2018.In the combined treatment group,30 cases were treated with compound glycyrrhizin injection at the site of facial rash,three times a week,four weeks as a course of treatment,while taking hydroxychloroquine sulfate tablets（100mg/tablet）daily,200 mg orally each time,twice a day.The control group only took 400 mg hydroxychloroquine sulfate tablets twice a day.All patients enrolled in this project were treated with moisturizing and repairing skin care products in the morning and evening.Both groups completed 4 weeks of treatment continuously.Before and after treatment,the two groups of patients were photographed by a special person under the same photographic condition.The same physician was assigned to observe the changes of the red area of the patients’ face before and after treatment with the digital facial skin analysis system（Visia）.A questionnaire survey was conducted by Rosacne Quality of Life Scale.The changes of skin barrier function（skin oil content,cuticle water content,loss of water through epidermis）were recorded in detail before and after treatment.Within three months after treatment,the patients were followed up to observe the recurrence of the disease,and the data were collected for comparative analysis and statistical treatment.Results: 1.After statistical treatment,there was no significant difference in age,gender,and disease severity between the combined treatment group and the control group（P>0.05）.2.After treatment,4 patients had transient mild facial erythema,tingling,itching and dryness.After cold compress with medical moisturizing dressing,the symptoms disappeared without affecting the treatment.3.In the treatment group,the water content in the cuticle increased significantly,and the water loss through the epidermis decreased significantly.There was a significant difference between the two groups in the efficacy and recurrence rate of skin barrier function repair（P<0.05）.4.Questionnaire survey showed that after treatment,the quality of life score of the two groups was lower than that before treatment,and the combined treatment group was significantly lower than that of the control group,the difference between the two groups was statistically significant（P<0.05）.Conclusion: The combined application of introducing Compound Glycyrrhizin Injection by pneumatic spray instrument and Hydroxychloroquine has a definite effect on the skin barrier function repair of rosacea with erythema capillary dilatation,and is better than the single use of hydroxychloroquine.Combined application can increase the repair effect of skin barrier function,which is safe,simple,convenient,low cost and high compliance of patients.It can be widely used in clinical treatment.