Correlation Analysis Of Clinical Characteristics For Sleep Phase-related OSAHS

Objective:To explore the characteristics of multiple related parameters and indicators of obstructive sleep apnea hypopnea syndrome(OSAHS)under different sleep phases,such as general demography,polysleep apnea monitoring(PSG)and inflammatory factor levels,and discuss the clinical characteristics and complication risk of OSAHS patients under different sleep phases,so as to guide the late clinical intervention measures and means.To further improve the understanding of REM-dependent low apnea hypopnea index(AHI)and improve the therapeutic effect of patients.Methods:A total of 1544 OSAHS patients admitted to the Sleep Medicine Department of Zhongshan Hospital of Traditional Chinese Medicine from January 2016 to April 2021 were selected.According to the different sleep phase,it can be divided into rapid-eye-movement dependent obstructive sleep apnea-hypopnea syndrome(REM-OSAHS,441 cases)and Non-rapid-eye-movement dependent obstructive sleep apnea-hypopnea syndrome(NREM-OSAHS,1103 cases).General demography,PSG parameters,expression levels of inflammatory factors and risk of complications were analyzed in the two groups.Results:In terms of general demography,the proportion of males in NREM-OSAHS(84.1%vs 59.9%,P<0.001),body mass index(BMI)(26.76±4.18 vs 25.76±3.64,P<0.001),Neck circumference(38.74±4.90 vs 36.71±4.40,P<0.001)and ESS score(9.00 vs 5.00,P<0.001)were higher than those in REM-OSAHS.In terms of PSG monitoring data,the AHI(33.10 vs 12.10,P<0.001),Nl%(30.96 ± 16.19 vs 20.59 ± 10.18,P<0.001),arousal index(15.50 vs 10.00,P<0.001),longest decline time of obstructive pulse oxygen saturation(44.50 vs 34s,P<0.001)in the NREM-OSAHS were higher than those in the REM-OSAHS,REM%(13.42±6.16 vs 14.79±5.95,P<0.001),N2%(48.73±12.90 vs 55.39±10.44,P<0.001),N3%(6.89±6.94 vs 9.23±7.52,P<0.001),LSpO2(76.23±14.25 vs 81.72±8.03,P<0.001)in the NREM-OSAHS were lower than those in the REM-OSAH.The REM AHI(22.66 vs 9.07,P<0.001)in mild OSAHS patients with REM-OSAHS was higher than the total AHI,and the number of NREM-OSAHS(229 vs 140,605 vs 27,respectively)was higher than the number of REM-OSAHS in patients with moderate and severe OSAHS(229 vs 140,605 vs 27,respectively).P<0.001).In terms of levels of inflammatory cytokines,Serum levels of hypersensitive C-reactive protein(hs-CRP),carbon dioxide binding force(CO2CP),mean platelet volume(MPV),platelet distribution width(PDW),platelet/lymphocyte ratio(PLR)and neutrophil/lymphocyte ratio(NLR)in the REM-OSAHS group were higher than those in the NREM-OSAHS group.In terms of the risk of complications,the morbidity of hypertension,type 2 diabetes mellitus and dyslipidemia in the REM-OSAHS of mild OSAHS patients was higher than that in the NREM-OSAHS.Conclusion:The clinical characteristics and complication risk of patients in the REM-OSAHS and the NREM-OSAHS are different to varying degrees,and the analysis of them is helpful to better understand the development process and severity of OSAHS disease.The analysis suggests that REN-dependent OSAHS with low AHI also require early intervention,.at the same time,the analysis can further guide the implementation and management of late clinical intervention measures,and improve the treatment and follow-up effects of patients.