After The Treatment Of Severe OSAHS Patients Before And After The Change Of Serum NSE Levels And Significance

ObjectiveBy detecting severe OSAHS patients before and after treatment the changesof serum NSE and MoCA score level, evaluation of CPAP therapy and surgicaltreatment in patients with severe OSAHS, the influence of which onpatients with severe OSAHS in cognitive function and NSE levels in thebrain injury.MethodsSelect100age <60years old by polysomnography (PSG) diagnosed withsevere OSAHS patients (37.8+/-12years old), in the second day afteradmission, CPAP therapy in7days, comprehensive treatment after3monthsfollow-up to determine the serum level of NSE, MoCA score at the same time.Assessment of severe OSAHS patients serum NSE levels and MoCA scoresituation, comparing three sets of changes of serum NSE levels and changesof three groups of MoCA score. Serum NSE detection experiment enzymelinked immunosorbent (ELISA) method.ResultsCPAP therapy in7days and3months postoperatively, patients with severeOSAHS after CPAP, predominantly surgical comprehensive treatment, theserum NSE level is on the decline, and treated with comparative differencewas statistically significant (P <0.05). CPAP therapy after7days ofMoCA score increase is not obvious, there was no statistically significant difference compared with the prior to admission, and surgical treatmentafter3months MoCA score rise significantly, compared with beforetreatment and CPAP therapy in7days difference was statisticallysignificant. NSE serum levels (or MoCA score) with severe OSAHS patientswith AHI, LSaO2, NSE serum levels are associated with the MoCA scores (P<0.05), which the serum level of NSE and AHI (r=0.652), LSaO2(r=0.681),MoCA score (r=0.682) significantly correlated; MoCA score with AHI (r=0.702), LSaO2significant correlation (r=0.657).ConclusionSevere OSAHS patients in the control confounding factors such as gender,age, body mass index, the serum level of NSE, MoCA score with AHI, LSa02relevance, to provide a theoretical basis for clinical treatment. SevereOSAHS patients with cognitive decline may repeatedly with long timehypoxemia, sleep disorders, structure is the factors affecting the MoCAscores.