The Clinical Efficacy Observation Of Bushen Huoxue Method On Mild Cognitive Impairment Of Cerebral Microblees With Cerebral Small Vascular Disease

Background and purpose: Cerebral Microblees(CMBs)is one of the markers to identify the severity of potential chronic small blood vessel disease,but also one of the imaging markers of small blood vessel disease,in the past due to technical limitations,people have insufficient understanding of it,with the maturity of MRI science and technology and more and more popular in clinical applications,in cerebrovascular disease,dementia and other patients and health examination applications more and more common,we are ischemic stroke,The presence of CMBs was found in the physical examination of cardiovascular and cerebrovascular patients such as dementia patients and in the physical examination of some elderly and healthy elderly people.There is a growing awareness of the disease and an increasing interest in the role of CMBs in cerebrovascular diseases.The disease may lead to a decrease in the patient’s cognitive,executive function,and information processing speed,as well as a compromise on quality of life.Multiple studies have shown that microhemorrhage is associated with mild cognitive impairment(MCI).MCI is now identified as a stage of dementia development,itself is reversible,grasp the early characteristics of the disease,according to the Chinese medicine "cure the disease" theory,can improve the patient’s memory loss,processing information speed decline and other clinical symptoms.This project aims to study the clinical efficacy of traditional Chinese medicine and modern medicine on cerebral microhemorrhage with mild cognitive impairment,in order to provide new thinking for the clinical combination of traditional Chinese and Western medicine in patients with cerebral microhemorrhage and mild cognitive dysfunction.Methods: The subjects(45-85 years old)were all patients who attended the Department of Neurology of the Affiliated Hospital of Tianjin Academy of Traditional Chinese Medicine from June 2020 to November 2020,and all patients underwent head MRI in line with the imaging characteristics of cerebral microhemorrhage and screened patients with mild cognitive dysfunction(renal deficiency and blood stasis type)on the scale,a total of 60 patients.Collect basic information such as the patient’s sex and age,as well as cognitive related data such as head MRI(including SWI),cognitive assessment scale,and daily life assessment scale.It was divided into 30 cases in the treatment group and 30 cases in the control group.The control group adopted general basic treatment and thinking forest oral administration,and the treatment group adopted general basic treatment and traditional Chinese medicine kidney and blood soup combined thinking forest oral administration.Both groups observed the MoCA,ADL,TCM syndrome table scores,TMT B,TMT B-A,and TMT A scores before and after treatment on a 24-week cycle,and used SPSS25.0 software to process and analyze the data.outcome:一、there were no statistical differences in the scores of the first two groups of patients in terms of age,sex,education level,MoCA,ADL,TMT A,TMT B,TMT B-A,and TCM syndrome table scores(P>0.05),which were comparable.二、Observation of the efficacy of kidney and blood soup on CMBs and MCI:1.Comparison between MoCA,ADL,TMT A,TMT B,TMT B-A,TMT B-A,TCM Phenometer scores in the treatment group before and after treatment(P<0.05);2.The treatment group and the control group compared the two groups of patients:MoCA,ADL,TMT A,TMT B,TMT B-A,TMT B-A,TCM syndrome table scores have statistical differences(P<0.05);3.Comparison between MoCA,ADL,TMT A,TMT B,TMT B-A,TMT B-A,TCM Phenometer scores before and after treatment in the control group did not have statistical differences(P>0.05);4.Correlation analysis between the number of CMBs and MoCA: After the Correlation Analysis of Spearman’s grade,the difference was statistically significant(rs=-0.682,P<0.001),and there was a negative correlation between the two levels.Correlation analysis between CMBs sites and MoCA: After The spearman grade correlation analysis,the difference was not statistically significant(rs=-0.202,P=0.122>0.05),and there was no negative correlation between the two levels.5.Safety evaluation: The enrolled subjects underwent blood,urine,stool routine,electrocardiogram,liver and kidney function examination before receiving treatment and after treatment,and there were no serious adverse reactions.conclusion:1.Kidney blood supplement can improve the clinical symptoms of patients with micro-cerebral hemorrhage with mild cognitive dysfunction(renal deficiency blood stasis type).2.The clinical drug safety of kidney and blood soup is good.