Clinical Observation On The Treatment Of Mild Cognitive Impairment After Stroke Of Kidney Yin Deficiency And Blood Stasis Type With Zishen Huoxue Prescriptio

Objective:To explore the clinical efficacy and characteristics of Nourishing the Kidney and Invigorating Blood Formula in treating PSMCI with Deficiency of kidney yin and blood stasis,and to find an early and effective TCM treatment prescription that can delay or reverse the development of PSMCI to PSD,to Provide reference experience for PSMCI control.Methods:Sixty patients with PSMCI from the Department of Neurology,Affiliated Hospital of Hunan Academy of Traditional Chinese medicine were enrolled,the severity and efficacy of cognitive impairment were assessed with the Montreal Cognitive Assessment(Mo CA)and Mental State Examination Scale(MMSE)to assess overall cognitive function,Trail Making Test(TMT)to assess executive function,Boston Naming Test(BNT)to assess language function,Hopkins Verbal Learning Test(HVLT-R)to assess memory function,Clock Drawing Test(CDT)to assess executive function,the Activities of Daily Living Scale(ADL)to assess ability of daily living and the Chinese Medicine Evidence Rating Scale to assess clinical syndrome of traditional Chinese medicine.Patients were randomly divided into test group and control group,the test group was given Nourishing the Kidney and Invigorating Blood Formula,the control group was given Done Pezil Hydrochloride Tablets,the course of treatment was 12 weeks.Before and after treatment,the above-mentioned scales were evaluated and the data of blood routine,urine routine,stool routine,stool occult blood test and liver and kidney function were collected,and to evaluate the curative effect of overall cognitive function,ability of daily living and clinical syndrome of traditional Chinese medicine.Results: 1.Pre-intervention balanced analysis: the baseline data(sex,age,BMI,years of education,types of stroke,course of disease(days),comorbid diseases,life style,scores and indexes before treatment)of the trial group and the control group had no significant difference in distribution(P>0.05).2.The scores of all scales were compared before and after treatment: After 12 weeks of treatment,at overall cognitive function,there were significant differences in the scores of Mo CA and MMSE between the two groups before and after treatment(P<0.05),and there was significant difference in Mo CA between the two groups after treatment(P<0.05),but no significant difference in MMSE between the two groups after treatment(P>0.05).At executive function,there was no significant difference in TMT-A and TMT-B between the two groups before and after treatment(P>0.05).At language function,there was significant difference in BNT before and after treatment in the test group(P<0.05),but there was no significant difference in the control group(P>0.05).At memory function,there was significant difference in HVLT-R between the two groups before and after treatment(P<0.05),there was no significant difference in HVLT-R between the two groups after treatment(P>0.05).At executive function,there was no significant difference in CDT between the two groups before and after treatment(P>0.05).At ability of daily living,there was significant difference in ADL between the two groups before and after treatment(P<0.05),but there was no significant difference in ADL between the two groups after treatment(P>0.05).At clinical syndrome of traditional Chinese medicine,there were significant differences in traditional Chinese medicine syndromes between the test group and the control group before and after treatment(P<0.05),there were significant differences in traditional Chinese medicine syndromes between the test group and the control group after treatment(P<0.05).3.Post-treatment Effectiveness:Both groups could improve the scores of Mo CA,MMSE,ADL and TCM syndrome.There was significant difference in the effectiveness of Mo CA and TCM syndrome score between the two groups(P<0.05).Conclusion: Both Nourishing the Kidney and Invigorating Blood Formula and Donepezil Hydrochloride Tablets could improve the cognitive function,daily living ability and Chinese medicine symptoms of PSMCI patients,and Nourishing the Kidney and Invigorating Blood Formula has obvious advantages in improving Mo CA,BNT and Chinese medicine symptoms.