Analysis Of Clinicaland Biochemical Characteristics Of Patients With Polycystic Ovary Syndrome With Phlegm-Dampness Syndrome With Different Blood Fat Levels

Objective:To compare the differences of general clinical characteristics,sex hormone levels,glucose and fat metabolism indexes between PCOS patients with phlegm-dampness syndrome and non-phlegm-dampness syndrome,and analyze the differences and correlations of clinical and biochemical characteristics of PCOS patients with phlegm-dampness syndrome with different blood fat levels,so as to provide basis for clinical diagnosis and treatment of PCOS patients with phlegm-dampness syndrome.Methods:Based on the case data collected in the integrated clinical research information system,935 patients with PCOS were retrospectively included in the gynecological clinic of the First Affiliated Hospital of Heilongjiang University of Chinese Medicine from September 2014 to December 2021.Firstly,they were divided into 565 cases of phlegm-dampness syndrome group and 370 cases of non-phlegm-dampness syndrome group.The general clinical characteristics,sex hormone levels and glucose and fat metabolism indexes of the two groups were compared.Secondly,according to the diagnostic criteria of dyslipidemia,565 patients with phlegm-dampness syndrome were divided into normal blood fat group of phlegm-dampness syndrome,elevated blood fat margin group of phlegm-dampness syndrome,and hyperlipidemia group of phlegm-dampness syndrome.The differences of indexes among the three groups were compared,and Logistic regression analysis was conducted to analyze the independent influencing factors of abnormal fat metabolism according to whether PCOS patients with phlegm-dampness syndrome were accompanied by abnormal fats.Finally,437 PCOS patients with dyslipidemia were determined whether they were phlegm-dampness syndrome,and their independent influencing factors were analyzed by Logistic regression analysis.Results:1.In this study,there were 437 patients with dyslipidemia of PCOS,accounting for 46.7%.Among them,250 patients had elevated fat margins,accounting for 26.7%.187 patients had hyperlipidemia,accounting for 20%.There were 565 patients with PCOS of phlegm-dampness syndrome,accounting for 60.43%,among which 157 patients with PCOS of phlegm-dampness syndrome combined with elevated fats,accounting for16.79%,and 126 patients with hyperlipidemia,accounting for 13.48%.2.In this study,there were significantly differences in age,menarche age,SBP,DBP,body weight,BMI,WC,HC,WHR,SHBG,FINS,I120 and HOMA-IR between PCOS patients with phlegm-dampiness syndrome and non-phlegm-dampiness syndrome group.TG,LDL-C,non-HDL-C,APO-B,APO-B/APO-A in the phlegm-dampness syndrome group were markedly higher than those in the non-phlegm-dampness syndrome group,while HDL-C was markedly lower than that in the non-phlegm-dampness syndrome group(P< 0.05).3.The values of age,WHR,G120,FINS,I120 and HOMA-IR in the three groups were significantly increased with the increase of the degree of blood fat disorder.The level of SHBG gradually decreased significantly.The HC of normal blood fat group was markedly lower than that of elevated blood fat margin group.The DBP,DHEAS and FPG in normal blood fat group were markedly lower than those in hyperlipidemia group.The body weight,BMI and WC of elevated blood fat margin group and hyperlipidemia group were significantly higher than those of normal fat group(P<0.05).4.Binary logistic regression analysis showed that age,DHEAS,FPG and G120 were independent influencing factors of abnormal fat metabolism in PCOS patients with phlegm-dampness syndrome.Menarche age and SHBG were independent influencing factors of phlegm-dampness syndrome in PCOS patients with dyslipidemia(P < 0.05).Conclusions:1.PCOS patients are usually accompanied by dyslipidemia,and the proportion of dyslipidemia in PCOS patients with phlegm-dampness syndrome is higher than that in non-phlegm-dampness syndrome.In the patients with dyslipidemia phlegm-dampness syndrome PCOS,the patients with elevated fat lipid margins were the main ones.2.PCOS patients with dyslipidemia with young menarche age and low SHBG level were mostly identified as phlegm-dampness syndrome.3.PCOS patients with phlegm-dampness syndrome with abnormal glucose metabolism are more likely to develop fat metabolism disorders.