| Objective:By detecting the proportion of helper T cells(Th)l7 in peripheral blood and the level of interleukin(IL)-26 in serum of patients with psoriasis vulgaris(PV),the correlation between them and the severity of PV was analyzed..Methods:84 PV patients who were treated in the First Hospital of Shanxi Medical University from December 2017 to January 2019 were selected as the observation group,of which 40 patients were in the advanced stage and 44 patients were in the stationary stage;40 volunteers who underwent physical examination in the same period were selected as the control group.Flow cytometry(FCM)was used to detect the proportion of Th17 cells in the peripheral blood of two groups of patients,and enzyme-linked immunosorbent assay(ELISA)was used to detect the level of serum IL-26 in two groups of patients,and the correlation between them and PV lesion area and severity index(PASI)score was further analyzed.Results:The ratio of Th17 cells in peripheral blood and the level of serum IL-26 in observation group were significantly higher than those in control group(P < 0.05).The proportion of Th17 cells in peripheral blood and the level of serum IL-26 in advanced patients were significantly higher than those in quiescent patients(P<0.05).PASI score of advanced patients was higher than that of resting patients,and the difference was statistically significant(t=3.30,P<0.05).In the observation group,the proportion of Th17 cells in peripheral blood and the level of IL-26 in serum were positively correlated with PASI score(P<0.05),and the proportion of Th17 cells was positively correlated with the level of IL-26(P<0.05).Multiple regression analysis showed that Th17 and IL-26 were the influencing factors of PASI score of PV patients(P<0.05).Conclusion:Th17 and its secretory factor IL-26 may play an important role in the pathogenesis of PV,and its expression level can reflect the severity of the disease to some certain extent. |
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