The Correlation Analysis Of Psoriasis Vulgaris Between PASI Score And Th17 Cells And Adipocytokines

Objective: This paper is to study the incidence of psoriasis and symptom features by way of analyzing the general data of qualified cases with vulgar psoriasis. Then we explore the relationship between clinical characteristics, Th17 cell and adipocytokines in peripheral blood lymphocyte in patients with vulgar psoriasis and speculate the mechanisms relate to the clinical features in patients with vulgar psoriasis.Methods: 180 patients with psoriasis vulgaris were collected from the dermatological department of affiliated heping hospital and heji hospital of changzhi medical college between January 2015 and January 2016, they were diagnosed vulgar psoriasis by clinical and pathological examination, all cases accorded to the inclusion and exclusion criteria. 180 patients were divided into two groups. Group I, including 92 progressing psoriasis vulgaris patients and Group Ⅱ, including 88 stable psoriasis vulgaris patients. The psoriatic lesion area and severity index(PSAI) was used to evaluate the patients’ condition. 200 healthy volunteers from physical examition were selected randomly as control during the same time period. To carry out epidemiological survey that include demographic characteristics,medical history,family history, living habits,the distribution of psoriatic lesion etc. The flow cytometry method(FCM) was used to detect the proportion of Th17 cells, and the peripheral blood serum levels of Th17 cells related cytokines(IL-17、IL-21、IL-22、IL-6) and adipocytokines(adiponectin, leptin, resistin and omentin) were detected using enzyme linked immunosorbent assay(ELISA). The experimental data used SPSS16.0 to annalyze. All data were analyzed by using t-test,Analysis of Variance,chi-square test and rank sum test according to the character of date. Pearson correlation analysis was performed between variables. The value is 0.05 as a standard test.Results:(1)The clinical feature: The proportion of male and female patients with psoriasis is 1.47 to 1; There were no significant difference between the anverage ages, the first onset ages and the average course between men and women(P>0.05); The most common inducing factor was infection factor(40.00%, 56/140), the second was season factor(30.00%, 42/140) and the third was psychic factor(11.43%, 16/140); The most common patients were in the advanced stage(53.33%, 96/180); 25.56%(46/180) patients had a family history; The most common affected parts were lower limbs(90.00%, 162/180). The second were upper limbs(82.22%, 148/180) and the third were trunk(78.89%, 142/180). The least was mueosa(1.11%, 2/180); The most common lesion shape was plaque type(76.67%, 138/180); The most common concomitant disease was upper respiratory tract infection(22.78%, 41/180), the second was diabetes(21.67%, 39/180) and the third was hyperuricemia(17.22%, 31/180).(2) The proportion of Th17 cells and the levels of related cytokines: The proportion of Th17 cells and the levels of IL-17, IL-21, IL-22, IL-6 in peripheral blood in the psoriasis patients group was significantly higher than healthy control group(P<0.05). The expression level of Th17 cells, IL-17, IL-21, IL-22, IL-6 and the PASI score has positive correlationship in the psoriasis patients group(r=0.61, 0.59, 0.71, 0.64, 0.57, P<0.05).(3) The levels of adipocytokines: The levels of adiponectin and visfatin in peripheral blood in the psoriasis patients group was significantly lower than healthy control group, and the levels of leptin and resistin in peripheral blood in the psoriasis patients group was significantly higher than healthy control group(P < 0.05). The expression level of adiponectin and visfatin and the PASI score has negative correlationship in the psoriasis patients group(r=-0.69,-0.60, P<0.05), and the expression level of leptin and resistin and the PASI score has positive correlationship in the psoriasis patients group(r=0.70, 0.66, P<0.05).Conclusions:(1) The levels of Th17 cells and its related cytokines in peripheral blood lymphocyte in patients with vulgar psoriasis was significantly increased, and are closely related to the severity of psoriasis vulgaris, which may play important roles in the mechanism of vulgar psoriasis.(2) The levels of adipocytokines in peripheral blood lymphocyte in patients with vulgar psoriasis was significantly changed, and are closely related to the severity of psoriasis vulgaris, it was suggesting that the adipocytokines might be a potential target to evaluate the severity of psoriasis vulgaris.