Clinical Observation Of Jiawei Guipi Decoction In Treating Depression After Ischemic Stroke (Qi And Blood Deficiency Syndrome)

Objective:To explore the clinical efficacy of Jiawei Guipi Decoction on post-ischemic stroke depression(syndrome of deficiency of qi and blood),scientifically and objectively evaluates its safety and effectiveness,and provides more basis for the standardized diagnosis and treatment based on syndrome differentiation in the traditional Chinese medicine.Methods: The sixty patients with post-stroke depression of qi and blood deficiency were randomly divided into treatment group and control group,which each group was thirty patients.Both groups were given basic treatment,the control group was given oral flupentixton melitaxen tablet in addition to basic treatment,and the treatment group was given Jiawei Guipi Decoction in addition to the control group,for consecutive 8 weeks.The changes of Hamilton Depression Scale(HAMD)score,National Institutes of Health Neurological Impairment(NIHSS)score,Barthel index score,Pittsburgh Sleep Quality Index(PSQI)score and TCM syndrome score were compared between both groups before intervention,2 weeks after intervention and 8 weeks after intervention.Blood,urine,stool routine,blood glucose,liver and kidney function,coagulation function and other examinations were routinely monitored in both groups before and after treatment,and related adverse reactions were recorded.After the observation,the collected data were statistically analyzed to compare the difference in clinical efficacy between the two groups.Results:(1)During the treatment study,one case of the control group fell off,thirty cases of the final treatment group,and twenty-nine cases of the control group completed the study.(2)Comparison of clinical efficacy: After 8 weeks of treatment,the total effective rate of the treatment group was 89.66%,and that of the control group was 77.00%.Therefore,the clinical efficacy of the treatment group was significantly better than the control group,and the difference was statistically significant(P<0.05).(3)Before treatment,HAMD score,NIHSS score,Barthel index score,and TCM syndrome score of 2groups showed no statistically significant difference by t-test of two independent samples(P>0.05),indicating comparability.(4)Comparison of scores between the two groups after treatment: After the second week of treatment,HAMD score and TCM syndrome score in the treatment group were lower than those in the control group,and the differences were statistically significant by t-test of two independent samples(P<0.05);The NIHSS score and PSQI score of the treatment group were lower than the control group by t-test of two independent samples,and the difference was not statistically significant(P>0.05).The Barthel index score of the treatment group was higher than the control group,and the difference was not statistically significant by t-test of two independent samples(P>0.05).At the end of the 8th week of treatment,the HAMD score,NIHSS score,PSQI score and TCM syndrome score in the treatment group were lower than those in the control group,while Barthel index score was higher than the control group.The differences were statistically significant by t-test of two independent samples(P<0.05).(5)Comparison of scores between the two groups before and after treatment: After the end of the 2nd week of treatment,the HAMD score,NIHSS score and TCM syndrome score in the treatment group were lower than before treatment by paired sample t-test,the differences were statistically significant(P<0.05);The Barthel index score of the treatment group was higher than before treatment by paired t-test,and the difference was not statistically significant(P>0.05).The PSQI score of the treatment group was lower than that before treatment by paired t-test,the difference was statistically significant(P<0.05).The HAMD score,NIHSS score and PSQI score of the control group were lower than those before treatment by paired t-test,and the differences were statistically significant(P<0.05).The Barthel index score was higher than before treatment,and the TCM syndrome score was lower than before treatment,and the differences were not statistically significant(P>0.05).At the end of the 8th week of treatment,the HAMD score,NIHSS score,PSQI score and TCM syndrome score in the treatment group were lower than those at the end of the 2nd week of treatment by paired t-test,the differences were statistically significant(P<0.05);The Barthel index score was higher than that at the end of the second week,and the difference was statistically significant(P<0.05).The HAMD score,NIHSS score and PSQI score of the control group were lower than those at the end of the second week of treatment by paired t-test,and the differences were statistically significant(P<0.05).The Barthel index score was higher than that at the end of the second week,and the difference was not statistically significant(P>0.05).Compared with the score of TCM syndrome at the end of the second week of treatment,the paired t-test showed no statistical significance(P>0.05).At the end of the 8th week of treatment,the HAMD score,NIHSS score,PSQI score and TCM syndrome score in the treatment group were lower than before,while Barthel index score was higher than before treatment.They Paired t-test showed statistically significant differences(P<0.05).The HAMD score,NIHSS score,PSQI score and TCM syndrome score of the control group were all lower than before treatment by paired t-test,which the differences were statistically significant(P<0.05).The Barthel index score of the control group was higher than before treatment by paired t-test,which was no statistically significant difference(P>0.05).Conclusion:(1)The application of Jiawei Guipi Decoction combined with Western medicine in the treatment of post-ischemic stroke depression(syndrome of deficiency of qi and blood)shows that its curative effect is superior to the Western medicine,indicating that it has a definite clinical effect.(2)Before and after treatment the score results show that the type of deficiency of qi and blood in patients with depression after ischemic stroke using Jiawei Guipi Decoction and Flupentixol and Melitracen Tablets which can improve the symptoms of patients with depression and the TCM symptom.Besides,it can also promote the recovery of nerve defect in the function.What is more,to improve the curative effect of self-care ability and the sleep quality of daily life is more significant.And the clinical medication safety is higher,and the worth of clinical application.