Clinical Characteristics And Related Risk Factors Analysis Of Hepatitis B Liver Cirrhosis With Kidney Injury

Objective: To retrospectively summarize and analyze the clinical characteristics and related risk factors of kidney injury in patients with hepatitis B cirrhosis,aiming to reduce the incidence of kidney injury,delay the progression of the disease,and improve the survival of patients through early detection and treatment of related high risk factors rate and quality of life.Methods and subjects: 233 patients with hepatitis B and liver cirrhosis admitted to the First Affiliated Hospital of Guangxi Medical University from January 2018 to December 2020 were selected as the research objects.Based on serum creatinine,the estimated renal size was calculated by the MDRD formula Glomerular filtration rate(e GFR),and based on whether the estimated glomerular filtration rate is higher than the upper limit of the reference value as the standard,the study subjects are divided into kidney injury group and nonkidney injury group,and the general clinical data of the two groups of patients are retrospectively analyzed,Relevant laboratory indicators,comorbidities and complications,apply statistics to analyze the related risk factors of hepatitis B liver cirrhosis patients with kidney injury.Results: 1.Among the 233 patients,141 were in the non-kidney injury group and 92 were in the kidney injury group.The incidence of kidney injury was 39.48%.The average age of the kidney injury group was 52.87±10.24 years,and the average age of the non-kidney injury group was 44.36±9.09 years.The patients in the kidney injury group were older than those in the non-kidney injury group,and the difference was statistically significant(P<0.05);2.The univariate analysis results of related laboratory indicators showed that the nonkidney injury group and the kidney injury group were in age,hemoglobin,albumin,glutamyl transpeptidase,creatinine,cystatin C,urea,total cholesterol,and Child pugh score The difference in Child pugh classification was statistically significant(P<0.05);3.Compared with the non-kidney injury group,the renal injury group has a higher rate of combined hypoproteinemia,hepatic encephalopathy,ascites,spontaneous peritonitis,and cholelithiasis(P<0.05);4.The receiver operating characteristic curve(ROC curve)shows that in addition to creatinine,cystatin C and urea also have a certain value in the diagnosis of kidney injury.The area under the curve(AUC)is respectively: creatinine 0.861,cystatin C 0.773,Urea 0.724;5.Multivariate logistic regression analysis showed that age is an independent risk factor for kidney injury in patients with hepatitis B cirrhosis(OR value 1.106).Conclusion: 1.Hepatitis B cirrhosis complicated with hypoproteinemia,cholelithiasis,hepatic encephalopathy,ascites,spontaneous peritonitis will be prone to kidney injury;2.In addition to creatinine in patients with hepatitis B and liver cirrhosis,cystatin C and serum urea nitrogen are also good indicators of kidney injury;3.Age is an independent risk factor for hepatitis B liver cirrhosis patients with kidney injury,and the risk of kidney injury increases with age.