Analysis Of Risk Factors Associated With Liver Cirrhosis Of Hepatocellular Carcinoma

ObjectiveIN China, For more than80%Hepatocellular carcinoma(HCC) on the basis ofthe Liver Cirrhosis(LC).And the natural course from LC to the HCC stage about10to20years. Risk factor for HCC have been many reports, but most of them did notconsider the natural course. To avoid short-term course in LC which have not occurHCC,in fact have potential risk factors to HCC interfering the study results. This studyselect the course of LC more than10years (taking into account the crowd has enteredthe natural history of HCC incidence), as a control group of HCC to analysis riskfactors.To provide a more reliable reference for clinical prevention of HCC.MethodsA hospital-based1:1matching case-control study was conducted.Matchingconditions as gender and age,we recruited121cases of HCC and121cases in LC whichcourse disease more than10years as a control group from January2007to September2011. Office Excel to establish a database to collate data.Independent samples t-test wasused to compare variables between the two groups, the group count data were comparedwith chi-square test.Univariate Logistic regression was used to analyze those factors,and at last, we analyze factors with statistical significance through Multivariate Logisticregression to control confounding factors. All analyses were performed with SPSSsoftware (version13.0), P<0.05showed statistical significantly different.Results1. The research suggested that there was no significantly difference in prevalence of ageand gender between two groups.2. Results from Univariate Logistic regression suggested that following factors were associated with the incidence of HCC:family history of first-degree relatives of HCC.heavy alcohol abuse, long history of smoking, history of liver disease (alcoholic fattyliver disease), Other medical history (Type2diabetes mellitus), HBeAg-positivehepatitis B cirrhosis, hepatitis B DNA (>10^4copies/ml), no anti-viral treatment.Family history of second-degree relatives,family history of cancer,hepatitis B DNA(<10^4copies/ml) of primary liver cancer showed no relation with HCC.3. The results of Multivariate Logistic regression showed following factors wereindependently associated with HCC: family history of first-degree relatives of HCC(OR=7.034,95%CI1.394-35.506), drinking scores (OR=5.009,95%CI1.475-17.010), smoking scores (OR=15.756,95%CI5.494-45.186), alcoholic fatty liverdisease (OR=13.749,95%CI1.559-121.231), history of diabetes (OR=4.030,95%CI1.490-10.899), HbeAg positive (OR=3.047,95%CI1.119-8.296), HBV DNA (10^4-10^5copies/ml)(OR=10.930,95%CI3.281-36.411), HBV DNA (10^5-10^6copies/ml)(OR=4.126,95%CI1.323-12.872), HBV DNA (10^6-10^7copies/ml)(OR=9.496,95%CI2.632-34.262), HBV DNA (10^7copies/ml)(OR=11.120,95%CI,1.737-71.163); no anti-viral treatment (OR=7.271,95%CI2.310-22.879).Conclusion1.LC with a history of first-degree relative of liver cancer has higher risk than those not.2.HBeAg-positive, HBV DNA>104copies/ml in LC has a relationship with HCC.3. The independent risk factors Associated with Liver Cirrhosis of HepatocellularCarcinoma: long-term smoking, heavy alcohol abuse,alcoholic fatty liver disease, Type2diabetes mellitus, no antiviral treatment.