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Supplementing Qi And Nourishing Yin Plus Chemotherapy To Treat Patients With ⅢB-Ⅳ Non-small Cell Lung Cancer Clinical Observation

Posted on:2019-09-25Degree:MasterType:Thesis
Country:ChinaCandidate:L J RenFull Text:PDF
GTID:2544305450951239Subject:Traditional Chinese Medicine
Abstract/Summary:PDF Full Text Request
ObjectiveTo observe the clinical benefit rate of supplementing qi and nourishing yin combined with chemotherapy in treating NSCLC with deficiency of qi and yin and its effect on immune function,serum tumor markers and chemotherapy toxicity.To evaluate the efficacy of supplementing qi and nourishing yin for the treatment ofⅢB-ⅣNSCLC with qi and yin deficiency.MethodsNinety patients with NSCLC who were enrolled in the study were randomly divided into control group and experimental group with 45 cases each.The control group was treated with the first-line chemotherapy regimen.The experimental group was treated with the combination of chemotherapy and Yiqi Yangyin prescription.Two groups are 21 days for a cycle,2 cycles for a course of treatment.The changes of tumor,immune function,tumor markers and toxicity were compared between the two groups before and after chemotherapy.Results1.The two groups in the evaluation of solid tumors,although no significant difference(P>0.05),but in the objective efficiency and disease control rate of the experimental group are higher than the control group.It shows that Yiqi Yangyin prescription combined with chemotherapy can improve the efficiency and control rate of stageⅢB-ⅣNSCLC.2.The serum CEA and CYFRA21-1 in both groups after treatment were lower than those before treatment,CA125 was higher than before,but no significant difference compared with before treatment(P>0.05).It shows that Yiqi Yangyin prescription has little impact in reducing tumor markers.3.The two groups’T lymphocyte subgroup has no obvious difference(P>0.05)before treatment.The levels of CD3~+and CD4~+in the experimental group were significantly higher than those before the treatment(P<0.05).The CD3~+decreased(P>0.05)and the CD4~+increased(P>0.05)in the control group after treatment,indicating that Yiqi Yangyin prescription can improve the immune function of patients with stageⅢB-ⅣNSCLC.4.In both groups,the number of leucocyte and neutropenia in the experimental group is less than that in the control group(P<0.05),and there is no significant difference in the other side reaction(P>0.05),but the experimental group were all less than the control group.It shows that Yiqi Yangyin Prescription can reduce chemotherapy-induced bone marrow suppression and it is safe and reliable to treatⅢB-ⅣNSCLC patients.ConclusionYiqi Yangyin can improve the objective effective rate and disease control rate of patients with stage ⅢB-Ⅳ NSCLC who have both Qi and Yin deficiency;Yiqi Yangyin can improve the immune function of patients with stage ⅢB-Ⅳ NSCLC who have both qi and yin deficiency;Yiqi Yangyin has protective hematopoietic function reduces the adverse reaction in patients with stage ⅢB-Ⅳ NSCLC who have both qi and yin deficiency.
Keywords/Search Tags:non-small cell lung cancer, yiqi yangyin, chemotherapy
PDF Full Text Request
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