The Clinical Effect Of Yiqi Jianpi Huashi Prescription On Impaired Glucose Regulation Of Spleen Deficiency And Damp Abundance

Objective: Based on the Erchen combined with Wendan soup,the spleen dehumidification method intervened in patients with impaired spleen deficiency,observe the clinical effect and safety,and try to provide more options for patients with impaired glucose regulation.Method: Seventy-four patients with impaired glucose regulation of spleen deficiency and dampness were selected and randomly divided into health education group(control group).Health education mainly related to diet and exercise was conducted once every two weeks,and basic knowledge of impaired glucose regulation was taught.Yiqi jianpi huashi prescription group(trial group): based on the control group,one dose of yiqi jianpi huashi prescription was taken every day,200 ml warm in the morning and evening.The changes of FPG,2h PG,BMI,Hb A1 c and TCM syndrome score were observed to evaluate the safety and effectiveness of invigorating qi and invigorating spleen and dehumidifying.Results:1.Overall curative effect of TCM: after 12 weeks of intervention,the total effective rate of the trial group was 71.42%,and that of the control group was 45.71%.The trial group was better than the control group(P < 0.05),with statistical difference.2.Overall curative effect of western medicine: the total effective rate of the trial group was71.42% and that of the control group was 54.42% after 12 weeks of intervention.Although the trial group was better than the control group,there was no statistical difference(P >0.05).3.Regulation of blood glucose: 4 weeks after intervention,blood glucose in both groups fluctuated compared with that before intervention,but there was no statistical significance(P > 0.01).After 8 weeks of intervention,FPG and 0.5h PG in trial groups were not significantly decreased compared with before intervention(P > 0.01),while 1h PG and 2h PG were significantly decreased compared with before intervention(P < 0.01).FPG,0.5h PG,1h PG and 2h PG in the control group were not significantly decreased compared with those before intervention(P > 0.01).After 12 weeks of intervention,FPG,0.5h PG,1h PG and2 h PG in trial groups were significantly decreased compared with before intervention(P <0.01);FPG,0.5h PG,1h PG and 2h PG in the control group were significantly decreased compared with those before intervention(P < 0.01).After 12 weeks of intervention,there was no significant difference in FPG and 0.5h PG between groups(P > 0.05).There were statistically significant differences between groups at 1h PG and 2h PG(P < 0.05).The Hb A1 c in trial group(5.70±0.38)was significantly decreased compared with that before intervention(6.03±0.23)(P < 0.01),and the Hb A1 c in control group(5.75±0.30)was also significantly decreased compared with that before intervention(5.96±0.20)(P < 0.01),and there was no statistical significance between groups(P > 0.05).4.Effect on BMI: After 12 weeks of intervention,in the trial group,BMI(23.13 ± 2.66) decreased significantly compared with preintervention(27.41 ± 2.77)(P <0.01),in the controul group,BMI(25.71 ± 2.95)decreased significantly compared to preintervention(27.60 ± 2.93)(P <0.01),and there was significant between groups(P <0.01).5.Improvement of TCM syndrome: After 12 weeks of intervention,the TCM symptoms score of test group(6.03 ± 2.91)decreased significantly compared with pre-intervention(12.91 ± 3.27)(P <0.01),the TCM symptoms score of control group(8.29 ± 3.97)was significantly lower compared with pre-intervention(11.26 ± 3.80)(P <0.01),The trial group improved the TCM syndrome better than the control group with a significant statistical difference(P <0.01).Conclusion:1.Yiqi Jianpi Huashi prescription can reduce the blood glucose level of patients with spleen deficiency and dampness.2.Yiqi jianpi Huashi prescription can reduce the body weight of patients with spleen deficiency and dampness type of sugar regulation,improve the symptoms and signs of patients.3.The intervention effect of Yiqi Jianpi Huashi prescription combined with lifestyle on postprandial blood glucose,BMI and TCM symptoms of patients with impaired glucose regulation of spleen deficiency and dampness type is better than that of lifestyle adjustment alone.