| ObjectiveIn this paper,the clinical manifestations and examination results of children with rotavirus-positive benign infantile convulsions associated with mild gastroenteritis（BICE）will be retrospectively analyzed,so as to clarify the clinical characteristics of rotavirus-positive BICE,explore the risk factors related to the occurrence of BICE after rotavirus infection,and explore the relevant examination indicators with clinical guiding significance.Methods49 children with BICE hospitalized from November 30,2020 to November 30,2021 were selected,and 20 of the children were positive for stool rotavirus,namely the BICE rotavirus positive group（observation group）.There were 29 children with negative stool rotavirus,namely BICE rotavirus negative group（control group A）.At the same time,40 children with rotavirus enteritis without convulsion were randomly selected as the rotavirus enteritis group（control group B）.All patients were between6 months and 3 years old.The relevant clinical data of all the children meeting the standards were collected,including age,sex,main clinical manifestations（vomiting,diarrhea,convulsion,etc.）,blood routine,blood ions,liver function,myocardial enzyme spectrum,stool rotavirus test results,brain imaging examination,electroencephalogram,etc.The clinical characteristics and laboratory results of the three groups were compared and analyzed.ResultsThe age range of observation group ranged from 13 to 29 months,with an average age of 19.65±4.52 months,of which 55.0% were 18-24 months,mainly occurring from December to May of the following year,about winter and spring.The symptoms of gastroenteritis in the observation group and control group A were both prior to the onset of convulsion,and the interval between convulsion and gastroenteritis was within 72 hours,with an average of 1.5 ± 0.6 days in the observation group.In the observation group,80.0% of the children had generalized seizures,90% had convulsions lasting less than 5 minutes,60.0% had convulsions lasting more than 2 times,and 85% had convulsions lasting less than 3 times.Compared with the control group A,there was no statistical significance in the interval time of convulsion,the type of convulsion,the duration of convulsion and the number of convulsions in a single course between the two groups（P >0.05）.Compared with control group A,aspartate aminotransferase and creatinase isoenzymes in observation group were significantly increased,while total protein was decreased,with statistical significance（P < 0.05）.Compared with control group B,the concentration of sodium,chlorine and prealbumin in the observation group was significantly decreased,while the concentration of potassium was significantly increased,with statistical significance（P < 0.05）.One child of observation group had high signal in cerebral MRI diffusion weighted imaging（DWI）of corpus callosum.It was a suspicious reversible splenial lesion syndrome（RESLES）,and the other children’s were normal.The EEG of 2 children in control group A showed slow background rhythm,and the EEG returned to normal one week later,and the other children’s were normal.Conclusions1.The onset peak age of rotavirus-positive children with BICE is 18-24 months,and the incidence is most frequent in winter and spring,with the highest incidence in January to May and December.2.Mild gastroenteritis symptoms in children with rotavirus-positive BICE and non-rotavirus-positive BICE are often preceded by convulsions,which are mainly characterized by multiple generalized attacks,lasting for less than 5 minutes,and no more than 3 attacks in a single course.3.In the biochemical indexes of rotavirus-positive children with BICE,except for the characteristics of rotavirus enteritis,namely,the increase of aspartate aminotransferase and creatine kinase isoenzyme,the prealbumin concentration decreased more significantly,suggesting that the prealbumin concentration in blood may be a test index to predict BICE,which has the value of further research. |
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