Quality Of Life And Its Influencing Factors In Prostate Cancer Patients Undergoing Endocrine Therapy

Objective: The purpose of this study was to comprehensively evaluate the quality of life of patients diagnosed with prostate cancer and treated with endocrinology alone by using the Chinese version of QLQ-C30 V 3.0 and the prostate cancer specific module scale QLQ-PR25,to understand the current status of patients’ quality of life and analyze the possible influencing factors.Methods: In this cross-sectional study,151 patients were surveyed by using the self-designed general data questionnaire,the Chinese version of the cancer patient quality of life rating scale QLQ-C30 V3.0 and the prostate cancer specific module scale QLQ-PR25.The scores of each dimension of the scale were taken as dependent variables,and the variables of general data were taken as independent variables for analysis,and the differences of different variables in each dimension of quality of life were compared.Significant variables from univariate analysis were included in multiple linear regression to further explore the factors affecting quality of life.P <0.05 indicated that the difference was statistically significant.Results: 1.Current situation of quality of life in patients undergoing endocrine therapy for prostate cancer.The QLQ-C30 scale showed that the overall health status of the patients was 71.03±18.85,and the quality of life was fair.Among functional areas,the cognitive function score was 94.37±12.31,which was the highest score.The score of physical function was 84.15±18.71,which was the lowest.In the symptom field,the fatigue score was 20.90±21.88,which was the highest;The score of nausea and vomiting was 1.66±7.14,which was the lowest.Among the six single items,the economic difficulty score was 30.24±33.41,which was the highest score.The diarrhea symptom score was 5.96±16.37,which was the lowest score.QLQ-PR25 scale showed that urinary tract symptom score was 19.59±20.18,which was the highest score.The intestinal symptom score was 3.81±6.36,which was the lowest score.The treatment-related symptom score was 9.64±9.89;In the field of sexual function status,the score of sexual interest was 1.32±6.24,the score of sexual pleasure was 0,and the score of sexual life quality was 77.78±31.43.2.Univariate analysis: marital status,concomitant diseases,course of disease and disease stage were the influencing factors of overall living status;Concomitant disease,Gleason score and disease stage were the influencing factors of somatic function.Concomitant diseases,number of channels and disease stage were the influencing factors of role function.Disease stage is the influencing factor of emotional function.Marital status,concomitant diseases and disease stage were the influencing factors of cognitive function.Concomitant diseases and disease stages are the influencing factors of social function.Age,concomitant diseases and disease stage were the influencing factors of fatigue symptoms.Disease stage was the influencing factor of nausea and vomiting.Concomitant disease,course of disease and stage of disease are the influencing factors of pain symptoms.Gleason score and disease stage were the influencing factors of insomnia symptoms.Place of residence,marital status,concomitant diseases,number of ducts,Gleason score and disease stage were the influencing factors of anorexia symptoms.Age is the influencing factor of constipation symptoms;Occupation and religious belief are the influencing factors of diarrhea symptoms.Age,occupation,monthly family income,payment method of medical expenses and stage of disease are the factors that influence economic hardship.Marital status and educational level were the influencing factors of urinary tract symptoms.Education level is an influential factor in the treatment of related symptoms.3.Multivariate analysis: comorbidities and disease staging significantly affected overall quality of life.Gleason score and disease stage significantly affected somatic function.Concomitant diseases,number of channels and disease stage significantly affected role function.Disease stage significantly affected emotional function;Marital status,concomitant diseases and disease stage significantly affected cognitive function.Disease staging significantly affected social functioning;Age and disease stage had significant influence on fatigue symptoms.The symptoms of nausea and vomiting were significantly affected by disease stage.Concomitant diseases significantly affect pain symptoms;Insomnia symptoms were significantly affected by disease stage.Place of residence,comorbidities,Gleason score and disease stage significantly affected anorexia symptoms.Age significantly affected constipation symptoms;Occupation and religion had significant influence on diarrhea symptoms.Age and disease stage significantly affect economic hardship.Conclusion:(1)The overall health and function of the endocrine therapy patients for prostate cancer included in the study were good,but the economic difficulties were particularly serious for the patients,which directly affected the quality of life and required the continuous improvement of medical security by the state and society.The influence of other symptoms on the quality of life should not be ignored,and should be paid attention to extensively and strengthened coping guidance.(2)the endocrine therapy of prostate cancer patients quality of life of affected by many factors,and the influence factors of different areas is not the same,in clinical medical care to cope with life quality comprehensive assessment,promote the individual treatment scheme selection and optimization,at the same time of prolong patient life to achieve the best quality of life.