Study On The Correlation Between Helicobacter Pylori Infection And Risk Factors Of Coronary Heart Disease And Degree Of Coronary Artery Stenosis

Objective we aim to examine the correlation between HP infection and risk factors of coronary heart disease and severity of coronary atherosclerosis in patients with coronary heart disease.This study provides practical reference value for clinical prevention and treatment of coronary heart disease with HP infection.Methods From March 2017 to November 2018,135 patients with CHD confirmed by coronary angiography were enrolled in the study.According to 14 C breath test,CHD patients were divided into HP positive group and HP negative group,87 HP positive group and 48 HP negative group.General data,clinical biochemical data and coronary angiographic results were collected,including sex,age,smoking history,family history,height,weight,hypertension history,diabetes history and so on.Clinical biochemical data included:High density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C),triglycerides(TG),total cholesterol(TC),blood sugar,hypersensitive C-reactive protein(hs-CRP),etc.Compare HP infection with the above risk factors.Two angiographic scores(angiographic severity score and Gensini score)were used to quantitatively evaluate the correlation between risk factors of coronary heart disease and the degree of coronary artery stenosis,and to explore the relationship between risk factors and HP infection.Results(1)There were significant differences in HDL-C,LDL-C,TG,TC and hs-CRP between HP positive group and HP negative group(P < 0.05);there were no significant differences in age,sex,body mass index(BMI),blood sugar,smoking history,diabetes history,hypertension history and family history between the two groups(P >0.05).(2)Multivariate logistic regression analysis showed that there was a significant correlation between HDL-C,hs-CRP and HP infection(P < 0.05).(3)Gensini score was used to represent the severity of coronary artery stenosis.The results showed that TC,TG,LDL-C and hs-CRP increased with the severity of coronary artery stenosis,while HDL-C decreased with the severity of coronary artery stenosis.There was significant difference between groups(P < 0.05).(4)The severity of coronary artery stenosis was represented by angiographic severity score.The results showed that TC,TG,LDL-C and hs-CRP increased with the severity of coronary artery stenosis,while HDL-C decreased with the severity of coronary artery stenosis.There was significant difference between groups(P <0.05).(5)Spearman correlation analysis showed that hs-CRP was positively correlated with Gensini score and angiographic score(r=0.399,P<0.05;r=0.342,P<0.05).HDL-C was negatively correlated with Gensini score and angiographic score(r=-0.116,P<0.05;r=-0.131,P<0.05),and TC was positively correlated with angiographic score(r=0.131,P<0.05).There was no significant correlation with Gensini score.(6)There was no significant difference in Gensini score(P = 0.756)and angiographic severity score(P =0.125)between HP positive and HP negative groups(P > 0.05).Conclusion(1)HDL-C and hs-CRP are risk factors for CHD with HP infection.(2)HDL-C was negatively correlated with the severity of coronary artery stenosis,while hs-CRP was positively correlated with the severity of coronary artery stenosis.(3)HP infection in patients with coronary heart disease may not be related to the severity of coronary artery stenosis.