Analysis Of Coronary Heart Disease In Patients With Helicobacter Pylori Infection And Its Affected Factors

Objectives To analyze the Coronary atherosclerotic heart disease(CHD)in patients with Helicobacter pylori(HP) infection and its influencing factors, and further explore the relationship among normal serum biochemical, Homocysteine(Hcy) and inflammatory, such as High-sensitivity c-reactive protein(hs-CRP), Intercellular adhesion molecule-1(ICAM-1), Heat shock protein60(HSP60), in order to provide some reference value for clinical diagnosis and treatment.Methods The research objects were 237 patients who diagnose with CHD and14 C breath test for detection, North China University of Science and Technology Affiliated Hospital, from 2013 September to 2014 December.According to the inclusion and exclusion criteria, the14 C breath test result is divided into 175 cases of HP infection in positive and 62 cases of HP infection in recessive. All of the patients in the current study who accepted the general situation investigation, medical history and physical examination and analyzing the clinical data, normal serum biochemical, Hcy and inflammatory factors of the clinical patients.Data processed by using SPSS22.0 statistics,measurement data represented for sx ±, t for group check, count data represented for %,χ2for group check. Analyzing the related factors of CHD patients with HP infection by using multivariate Logistic regression analysis.Results 1 The status of CHD infection in 237 patients with HP was 73.8%, among them the status of HP in patients with acute coronary syndromes was78.1%, the status of HP in patients with stable angina pectoris was 64.9%, differences among groups were Statistically significant(P<0.05). 2 Groups of patients with coronary heart disease serum biochemical parameters TC: 4.62±1.15 mmol/L vs 3.82±0.88 mmol/L; TG: 0.12±0.20 vs0.33±0.20, HDL-C: 1.34±0.31 mmol/L vs 1.58±0.38 mmol/L, LDL-C: 2.61±0.86mmol/L vs 2.25±0.68 mmol/L, ALT: 1.34±0.27 vs 1.21±0.23, BUN: 6.21±1.84 mmol/L vs 5.62±1.85 mmol/L, GLU: 6.05±1.63 mmol/L vs 5.30±0.81 mmol/L, differences among groups were Statistically significant(P<0.05). 3 Groups of patients with coronary heart disease Hcy: 4 Groups of patients with coronary heart disease inflammatory factors,hs-CRP: 0.78±0.50 mg/L vs 0.61±0.47 mg/L, HSP60: 2001.35±385.75 ug/ml vs1446.72±280.02 ug/ml, ICAM-1: 540.16±113.53 ug/L vs 334.87±78.47 ug/L, groups were significant differences(P<0.05). 5 Statistical significance of CHD in patients with HP infection index to the multifactor Logistic regression analysis, TC:(OR=5.190,1.396~19.298 95%CI), TG:(OR=0.235, 0.073~0.753 95%CI), HDL-C:(OR=0.401,0.172~0.934 95%CI), HSP60:(OR=1.020, 1.005~1.035 95%CI), ICAM-1:(OR=1.208,1.028~1.421 95%CI), differences among groups were Statistically significant(P<0.05).Conclusions 1 The status of HP in patients with acute coronary syndromes was higher than that in stable angina pectoris;2 CHD combined with HP infection is associated with TC, TG, HDL-C, HSP60, ICAM-1.