Study On The Correlation Between Some Syndromes Of Pulmonary Distension And Serum PTX3 Level

Purpose:the large molecules of disease of traditional Chinese medicine and modern medicine theory as the foundation,to detect lung distension heat phlegm yu lung syndrome and Yang deficiency type water made the two card between group patients serum is five poly protein 3（Pentraxin 3,PTX3）level as the main outcome measure,combining with TCM symptom scores blood tests Lung function and other auxiliary materials,and discusses the serum PTX3 type in the two lung syndrome group and the change rule of meaning,for of lung distension and provided a reference for clinical treatment.Methods:according to the inclusion criteria,30 cases of phlegm-heat stagnation of lung syndrome group and 30 cases of Yang deficiency and water invasion syndrome group were included in this study,a total of 60 cases.The four diagnostic data of the patients on the day of admission were collected for grading of pulmonary function（see the attached table for details）,and relevant auxiliary examinations were conducted,including White blood cell count（WBC）,Neutrophilic granulocyte percent（NEUT%）,High sensitivity C-reacity protein（hs-CRP）,FEV₁/FVC and FEV₁was the predicted value in pulmonary function tests.Serum PTX3 levels were detected by enzyme-linked immunosorbent assay（ELISA）.Statistical software was used to analyze the difference and correlation between symptom scores and auxiliary examination data of pulmonary function examination in PTX3 and pulmonary distension syndrome group.Results:1.Comparison of serum PTX3 in the two syndrome type groups:the serum PTX3level in the phlegm-heat depression of lung syndrome group was higher than that in the Yang deficiency and flooding syndrome group,P=0.003,P<0.01,the difference was statistically significant.2.Two card group serum PTX3 and TCM symptom score and pulmonary function classification comparison:phlegm hot yu lung syndrome patients serum PTX3 negative correlation with cough score,with significant statistical significance（P=0.00<0.01）,and negatively correlated with sputum score,asthma score,with statistical significance（P<0.05）,and no correlation asthma score,pulmonary function,no statistical significance（P>0.05）.There was no significant correlation between serum PTX3 and TCM symptom score and lung function grade（P>0.05）.3.Comparison of serum PTX3 and WBC,Neut%and hs-CRP in 2 syndrome type groups:there was no correlation between serum PTX3 level and WBC level in phutm-heat depression lung syndrome group,P=0.671,P>0.05,the difference was not statistically significant.Serum PTX3 level was positively correlated with Neut%and hs-CRP in phlegm-heat depression group（P=0.033,P<0.05,P=0.008,P<0.01）,and the differences were statistically significant.There was no significant correlation between serum PTX3and WBC,Neut%and hs-CRP（P=0.804,0.850,0.486,P>0.05）in the group of Yang deficiency and flooding syndrome.4.Comparison of serum PTX3 and FEV₁%of predicted value and FEV₁/FVC in 2syndrome type groups:serum PTX3 in phlegm-heat depression lung syndrome group increased with the decrease of FEV₁%of predicted value,showing a negative correlation（P=0.01,P<0.05）,which was statistically significant.PTX3 increased with the decrease of FEV₁/FVC,and there was a negative correlation between them（P=0.001,P<0.01）,which was statistically significant.Serum PTX3 and FEV₁%of the predicted value,and FEV₁/FVC had no correlation（P=0.074,0.595,P>0.05）in the group of Yang deficiency and flooding syndrome.There was no statistical significance.Conclusion:There was a certain correlation between PTX3 and lung distention heat obstructing lung syndrome group.With the aggravation of cough,expectoration,asthma and asthma,the increase of neut%and hs-CRP,the decrease of FEV₁/FVC,and the increase of serum PTX3,it indicates that PTX3 may participate in the pathological process of lung distention phlegm heat stagnation syndrome,suggesting that there may be different degrees of infection and lung function damage in phlegm heat stagnation syndrome.It is suggested that PTX3 has a certain reference value for the classification of pulmonary distension and the evaluation of the disease.