| ObjectiveClinically,dyslipidemia and ischemic stroke are often accompanied by two diseases.When suffering from both dyslipidemia and ischemic stroke,the patient’s risk of death will increase significantly.In this study,a cross-sectional study method was used to include patients who were clinically eligible for clinical diagnosis of dyslipidemia and ischemic stroke.Based on the clinical symptoms of Chinese medicine,the types of medical syndromes were determined,and the distribution of medical syndromes was analyzed.To study the correlation between different TCM syndrome types and PTX3 and hs-CRP,as well as the correlation between blood lipid and PTX3 and hs-CRP.Attempt to provide new objective basis for traditional Chinese medicine in clinical microscopic syndrome differentiation,and provide new ideas for traditional Chinese medicine treatment of dy slipidemia with ischemic stroke.MethodAccording to the corresponding diagnosis inclusion and exclusion criteria,102 patients who met the clinical diagnosis of dyslipidemia and ischemic stroke with traditional Chinese and Western medicine were screened,and 16 healthy medical examinees were selected as the control group to collect basic information such as four diagnosis and vital signs,Fill out the Chinese medicine syndrome type judgment scale,take fasting venous blood in the morning,test the indicators of blood lipid,PTX3 and hs-CRP,and finally analyze all data statistically.All the cases included in this study were from patients who attended dongzhimen hospital and dongfang hospital of Beijing university of Chinese medicine from March 2019 to December 2019.Result1 The 102 patients with dyslipidemia and ischemic stroke had an overall age distribution of 40-87 years old,with an average of 65.13 ± 10.23 years old,of which men had an average age of 64.35 ± 10.28 years old,and women had an average age of 67.18 ± 9.98 years old.There were 74 male patients(72.5%)and 28 female patients(27.5%).There were 48 patients(47.1%)with a history of drinking alcohol,and 57 patients(55.9%)with a history of smoking.Another 16 healthy people with normal blood lipids and no history of stroke were collected as the normal control group.The average age was 57.25± 7.99 years old,8 males(50.0%)and 8 females(50.0%).There were 7 patients(43.8%)with a history of drinking alcohol and 3 patients(18.8%)with a history of smoking.The cases of dyslipidemia with ischemic stroke were statistically different from the normal control group in smoking history,systolic blood pressure,body weight,and BMI(P<0.05).No statistics were found in drinking history,body temperature,breathing,diastolic blood pressure,and height Difference(P>0.05).2 Among the 102 patients with dyslipidemia and ischemic stroke,according to the statistical frequency of the sample,the TCM syndrome types were ranked from high to low,followed by 33 cases of phlegm and blood stasis syndrome(32.4%)>23 cases of Qi deficiency and blood stasis syndrome(22.5%)>21 cases of wind-phlegm obstruction syndrome(20.6%)>13 cases of yin deficiency and hyperactivity syndrome(12.7%)>12 cases of phlegm-heat syndrome(11.8%).3 The systolic blood pressure of patients with phlegm-heat organ syndrome,wind-phlegm obstruction syndrome,qi-deficiency blood stasis syndrome and phlegm-stasis syndrome are all higher than the normal control group,and have statistical significance(P<0.05).The weight and BMI of patients with phlegm and blood stasis syndrome were higher than that of normal control group,the difference was statistically significant(P<0.05).4 There are differences in blood lipid levels among various TCM syndrome types(P<0.05).The TC and HDL-C levels of the phlegm and blood stasis syndrome were the highest,the TG and LDL-C levels of the wind phlegm obstruction syndrome were the highest,the serum TG,TG and LDL-C levels were the lowest,and the serum HDL-C was confirmed The level is the lowest.However,there were no significant differences in the levels of TC,TG,LDL-C,and HDL-C among the syndrome types5 Serum PTX3 content in patients with dyslipidemia and ischemic stroke is higher than that in normal control group(P<0.05).There was no statistically significant difference in serum PTX3 content among different genders,ages,and BIM groups(P>0.05).According to the level of serum PTX3,the syndrome types were ranked from high to low,and the order was wind-phlegm-blocking syndrome>yin deficiency-yang hyperactivity syndrome>phlegm-heat organ syndrome>phlegm and blood stasis syndrome>qi deficiency and blood stasis syndrome>normal control group.There was a statistically significant difference between the syndrome of Yin deficiency and Yang hyperactivity,the syndrome of wind phlegm obstruction and the normal control group(P<0.05).6 The serum hs-CRP content in patients with dyslipidemia and ischemic stroke is higher than that in the normal control group(P<0.05).In different age groups,the hs-CRP content in the elderly group and the elderly group is significantly higher than that in the middle-aged group,the difference It has statistics(P<0.05),and there is no statistical difference between different genders and BIM groups(P>0.05).According to the serum hs-CRP level,the syndrome types were ranked from high to low,and the order was phlegm and blood stasis syndrome>phlegm and heat syndrome>yin deficiency and yang hyperactivity syndrome>wind phlegm obstruction syndrome>qi deficiency blood stasis syndrome>normal control.The phlegm and blood stasis syndrome is statistically different from the normal control group(P<0.05).7 Correlation analysis showed that serum PTX3 levels were positively correlated with LDL-C,with statistical significance(P<0.05),and negatively correlated with HDL-C,with statistical significance(P<0.05),with TC,TG No obvious correlation was found(P>0.05).There was no significant correlation between serum hs-CRP level and TC,TG,LDL-C,HDL-C(P>0.05).Serum PTX3 level was positively correlated with systolic blood pressure,with statistical significance(P<0.05),and had no significant correlation with body temperature,heart rate,respiration,diastolic blood pressure,age,height,weight,BMI(P>0.05).Serum hs-CRP level was significantly positively correlated with age,with statistical significance(P<0.05),and had no significant correlation with body temperature,heart rate,respiration,blood pressure,height,weight,BMI(P>0.05).There was no significant correlation between serum PTX3 and hs-CRP(P>0.05).Conclusion1 The TCM syndromes of patients with dyslipidemia and ischemic stroke were mainly phlegm-stasis syndrome,qi-deficiency blood-stasis syndrome and wind-phlegm syndrome,while phlegm-heat and fu-evidence and Yin deficiency and Yang hyperactivity syndrome were relatively few.2 Patients with phlegm and blood stasis syndrome had the highest TC content,the highest TG and LDL-C levels in patients with wind-phlegm syndrome and collateral-blocking syndrome,the lowest serum TG,TG and LDL-C levels in patients with Yin deficiency and Yang hyperactivity syndrome,and the lowest serum HDL-C levels in patients with phlegm heat and fu syndrome.3 The content of serum PTX3 was the highest in patients with wind-phlegm syndrome and Yin deficiency and Yang hyperactivity syndrome,and the content of serum hs-crp was the highest in patients with phlegm and blood stasis syndrome and phlegm heat-fu syndrome.4 There was a certain correlation between serum lipid level and serum PTX3 level in patients with dyslipidemia and ischemic stroke:serum PTX3 level was positively correlated with LDL-C,and negatively correlated with HDL-C. |
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