Study On The Correlation Between Lung Distension And Clara Cell Secretory 16-kd Protein

Objective:To investigate the changes and significance of serum CC16 in the lung distension phlegm-heat stagnation lung syndrome group and the yang-deficiency water-pan syndrome group,so as to provide laboratory reference indexes for the diagnosis of lung distension syndrome type in traditional Chinese medicine,improve the accuracy of lung distension syndrome classification and improve the clinical efficacy of traditional Chinese medicine.Methods:Strictly following the principle of random parallel control,a total of 76 cases were collected,including 40 cases in the sputum heat stagnation lung syndrome group as the observation group,and 36 cases in the Yang deficiency and water fanzheng syndrome group as the control group.Through gathering patients admitted to hospital on the day of the four diagnostic data,collect patients admitted to hospital on the first day of routine blood,Serum amyloid A（Serum amyloid A,SAA）,hypersensitive c-reactive protein（High sensitivity C-reactive protein,the hs-CRP）,pulmonary function,and the next day morning fasting venous blood in patients with,through quiet place（room temperature,20min）-centrifugal（8cm,3000r/min,10min）-serum separation-cryopreservation（-80℃）-thawing-detection（ELISA）and other steps to obtain serum CC16concentration.Statistical analysis was carried out on the serum CC16 level and auxiliary examination data of patients in the two syndrome groups to evaluate the correlation and difference between the two syndrome groups in the serum CC16 level and the auxiliary examination data.Result:1.Compared with the yang-deficiency and water-pan syndrome group,the serum CC16level in the phlegm-heat stagnation and lung syndrome group was significantly reduced,and the difference was statistically significant（P<0.01）.2.Compared with the group with yang-deficiency and water-pan syndrome,the levels of WBC,NEUT%,hs-CRP and SAA in the phlegm-heat stagnation lung syndrome group were significantly increased,and the difference was statistically significant（P<0.05）.3.Compared with the group with yang-deficiency and water-pan syndrome,FEV₁accounted for the predicted value of%and FEV₁/FVC slightly higher in the phlegm-heat stagnation and lung syndrome group,with no statistically significant difference（P>0.05）.4.The CC16 level in the phlegm-heat stagnation lung syndrome group decreased with the increase of WBC,NEUT%,hs-CRP and SAA levels,showing a negative correlation（P=0.004,r_s=-0.442）,（P=0.002,r_s=-0.479）,（P=0.044,r_s=-0.320）,（P=0.009,r_s=-0.410）.There was no correlation between the Yang-deficiency-water-pan-syndrome group and the above laboratory indicators（P>0.05）.5.The CC16 level in the phlegm-heat stagnation lung syndrome group increased with the increase of FEV₁ in%of the predicted value,which was positively correlated with FEV₁in%of the expected value（P=0.000,r_s=0.703）,and had no correlation with FEV₁/FVC（P>0.05）.There was no correlation between CC16 level and FEV₁%and FEV₁/FVC（P>0.05）.Conclusion:CC16 level of lung swelling phlegm heat depression syndrome is negatively correlated with WBC,hs-CRP,NEUT%and SAA levels.CC16 level decreases with the increase of WBC,hs-CRP,NEUT%and SAA levels.CC16 may be involved in the inflammatory reaction process of lung swelling phlegm heat depression syndrome.