| Objective: To observe the clinical efficacy of Professor Zhou Yi’s self-made Shugan Zhiwei Decoction in the treatment of chronic atrophic gastritis with stagnation of liver and stomach qi,to explore its onset mechanism and medication basis,and to provide ideas for the treatment of atrophic gastritis with stagnation of liver and stomach qi.Discuss the etiology and pathogenesis of atrophic gastritis,the classification of syndromes and the methods of differentiation and treatment,the etiology and pathogenesis of western medicine,the diagnostic criteria and classification,the treatment plan,etc.Methods: A total of 66 patients with chronic atrophic gastritis diagnosed by Western medicine in the inpatient department of Huayuanshan Spleen and Stomach Diseases Department of Hubei Provincial Hospital of Traditional Chinese Medicine and Director Zhou Yi’s Specialist Outpatient Clinic from October 2019 to 2020.Divided into treatment group and control group,each group has 31 subjects.The control group was treated with Morodan,taking: 8capsules/time,3 times/day,half an hour after breakfast,lunch,and dinner;the treatment group was treated with syndrome differentiation Chinese medicine prescription Shugan Zhiwei Decoction,200 ml of water decoction,morning and evening Each time,warm one hour after meal.The total course of treatment is 3 months.Each subject will undergo gastroscopy once before and after treatment,take biopsy,perform blood analysis,urinalysis,stool analysis,and electrocardiogram.Observe the changes in TCM syndrome scores and TCM syndromes before and after treatment.Use statistical software SPSS 25.0 to statistically analyze the data obtained in the test,draw conclusions,and observe the safety of the test.Result: A total of 4 cases were dropped during the treatment,and the final treatment group was 31 observation subjects and the control group 31 observation subjects.General information: There was no significant difference between the two groups of test patients in terms of age,gender,and disease course composition ratio(P>0.05).The baseline data were consistent and comparable.TCM syndrome scores and curative effect: The main TCM syndromes(stomach pain,abdominal distension,hypochondriac pain),minor syndrome scores(noisy,belching,acid reflux),and total TCM syndrome scores were not significantly different between the two groups before treatment(P > 0.05),both are comparable;the comparison between the two groups before and after treatment shows that,except for acid reflux(P>0.05),the degree of decrease in the scores of other TCM syndromes is statistically significant(P<0.05).Among them,the two groups have stomach pain and abdominal distension.The degree of decrease in the score of hypochondriac pain was similar(P>0.05),and the degree of reduction in the score of noisy and belching was relatively significant.There were significant differences between the treatment group and the control group(P<0.05 or P<0.01).Comparing the total curative effect of TCM syndromes,both the treatment group and the control group are statistically significant(P<0.05 or P<0.01),and the treatment group is better than the control group(P<0.05).Efficacy of endoscopic mucosal inflammation: there was no significant difference in endoscopic mucosal inflammation between the control group and the treatment group before treatment(P>0.05);the comparison between the two groups before and after treatment showed that the difference in gastric mucosal inflammation was statistically significant(P<0.05).There was no significant difference in the degree of gastric mucosal inflammation in the comparison between groups(P>0.05).Pathology score and curative effect: The atrophy and intestinal metaplasia scores of the control group and the treatment group before treatment were compared,there was no significant difference between the two(P>0.05),and they were comparable;the two groups before and after treatment were compared within the group.,The difference in the degree of decline of atrophy score was statistically significant(P<0.05).The difference in the degree of decline of atrophy score between the two groups after treatment was not statistically significant(P > 0.05);the comparison between the two groups before and after treatment,The degree of decrease in intestinal metaplasia score was not statistically significant(P>0.05).After treatment,the comparison between the two groups of pathological efficacy groups and the pathological efficacy self-comparison,the above-mentioned differences between the treatment group and the control group were not statistically significant(P>0.05).Conclusion: Using Zhoushi Shugan Zhiwei Decoction to treat atrophic gastritis with liver and stomach qi stagnation syndrome can effectively alleviate the clinical symptoms of CAG.Among them,the improvement effect of noisy,belching and other symptoms are better than Morodan,and it is better for stomach pain,abdominal distension and hypochondriac pain.The relieving effect is equivalent to that of Morodan,but it has no obvious effect on acid reflux;it has obvious effects on the improvement of endoscopic gastric mucosal inflammation and the reversal of pathological grade of atrophy,which is equivalent to Morodan,but there is no definite evidence to prove the effect on the intestines.Epithelial metaplasia has a reversal effect. |
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