Clinical Study Of Treating Chronic Atrophic Gastritis With Zhiwei Decoction

Object iveTo observe the clinical curativate effect to treat of Chronic Atrophic Gastritis (type of noharmonious the stomach and liver)by Zhiwei decoction and to explore possible mechanism。MethodAccording to diagnosis standards, inclusion standards and elimination standards,60cases with Chronic Atrophic Gastritis are selected from the patient department and outpatient department of Sanya hosptial of TCM during February2012-August2013. All the cases are divided into two groups with random and comparison method. Each group involved30cases. The two groups in gender, age, course, mainly symptoms, signs, endoseopy and Pathology has no significant differences(P>0.05). Of which30are in the treatment group with the administration of Zhiwei decoction2times per day,30are in the control group was given triple therapy for the eradiction of Hp infection(Omeprazole po20mg bid, Clarithromycin po0.5g bid, Amoxicillin po1. Og bid), the cases accompanied indigestion subjoined Domperidone、Metoclopramid、Mosapride etc. The cases accompanied bile refluxion subjoined Talcid, the cases accompanied pernicious anemia subjoined VitB12and Folic aid. Two groups are three months of a course of treatment. Symptoms, signs, gastroscoptic and pathological changes of each group were observed before and after one course of treatment in eluding HP-killing rate.Result1. The curative effect of symptoms and signs:the effcient of two groups are equal (p>0.05), but the experimental groups on the degree of improvement all exceed the control group (p<0.05)2. The curative effect of gastroscope:the experimental group better than the other one on edema and erythema(p<0.05), not erosion、granule hyperplasia and visible artery (p>0.05)3.The curative effect of Pathology:the treatment group was much better than the control group on atrophy(p<0.05), but not IM and Dys (p>0.05)4. Hp killing rate:the treatment group was equal to the control group (p>0.05)ConclusionAccording to the clinical observation CAG, my tutor’s experience prescriptions less than the efficacy of western medicine no matter improvement on symptoms and signs or gastroscope and pathology.