An Analysis Of The Correlation Between Cholecystectomy And Metabolic Syndrome

Objective:To analysis the correlation between cholecystectomy and metabolic syndrome.Methods:Random sampling was conducted from the physical examination population of our hospital from 2015 to 2017,and data such as age,gender,height,weight,blood pressure,fasting blood glucose,triglyceride,high-density lipoprotein and waist circumference were collected and patients who had undergone cholecystectomy in our hospital were screened out.The preoperative data were reviewed and grouped for statistical analysis.The measured data for t-test,and counted data for chi-square test.P<0.05 was considered statistically significant.Result:Results:According to Chinese Diabetes Society’s Metabolic Syndrome(MS)diagnostic criteria in 2013,the cross-sectional study(N=2385)suggested that Compared with the unoperated group of gallbladder stones(hereinafter referred to as the unoperated group),the indexes related to metabolic syndrome in the cholecystectomy group were:the prevalence of metabolic syndrome(38.3%vs 30.7%,X~2=9.556,P<0.005);high-density lipoprotein(1.26±0.30 mmol/L vs 1.32±0.35 mmol/L,P<0.001);triglyceride(2.01±1.37 mmol/L vs 1.73±1.55 mmol/L,P<0.001);waist circumference(88.72±9.40 cm vs 85.49±9.27 cm,P<0.001);BMI(25.17±3.18 kg/m~2 vs 24.30±3.24 kg/m~2,P<0.001);however,the percentage of impaired fasting glucose of the cholecystectomy group(23.1%)was lower than that of the unoperated group(30.7%),P<0.005;when comparing cholelithiasis group with non-cholelithiasis group,the difference in the prevalence of systolic blood pressure,fasting blood glucose,waist circumference,BMI,MS was statistically significant.According to Chinese Diabetes Society’s Metabolic Syndrome(MS)diagnostic criteria in 2004,the cross-sectional study(N=4584)suggested that the results of the cholecystectomy group compared with the unoperated group were:the prevalence of metabolic syndrome(21.0%vs15.5%,X~2=14.345,P<0.001);high density lipoprotein(0.63±0.40mmol/L vs 1.38±0.35 mmol/L,P<0.001);triglyceride(1.83±1.30mmol/L vs 1.50±1.28 mmol/L,P<0.001);BMI(24.59±3.14 kg/m~2 vs24.11±2.92 kg/m~2,P<0.001).There were significant differences in MS-related factors between the cholelithiasis group and the non-cholelithiasis group.Triglyceride increased from 1.60±0.95 mmol/L to 1.90±1.28 mmol/L,within 3 years after cholecystectomy,P=0.010.All observations after 3 years of operation were in line with the expected changes,and were statistically significant.Conclusion:From this research we are still unable to infer whether cholecystectomy will increase the risk of metabolic syndrome,but from this cross-sectional study,fasting blood glucose and triglyceride elevation in patients after cholecystectomy can be observed.