Risk Factors Of Gallbladder Stones After Gastric Cancer Surgery And The Value Of Prophylactic Cholecystectomy

Objective Great deal of study has proved that the incidence of gallstone was high after the gastrectomy for gastric cancer, but the mechanism of the deuteropathy and the value of the prophylactic cholecystectomy were in suspense. In this study, retrospective analysis was used to investigate the risk factors of the deuteropathy and to assess the prophylactic cholecystectomy synchronously with the gastric cancer surgery.Methods The data from 414 patients with gastric cancer were retrospectively analyzed. Patient parameters including gender, age, disease history, Bus, blood biochemical and electrolyte examination, operation method and perioperative blood transfusion were assessed.Results The incidence of the deuteropathy was 11.0%, which was occurred within 3months mostly and was increasing within 2 years. There were no relationship between the deuteropathy and the preoperative gallbladder polyps, cholesterol crystallization and cholecystitis(P>0.05). Abnormal fasting glucose(FPG≧6.1mmol/l) was a risk factor of the deuteropathy(P=0.016). The incidence was higher in patients with the formation of gallbladder sludge than that in patients without the forming(P =0.002). In addition,dyspepsia was occurred in 29(59.2%) patients who had undergone non-surgical treatment.Conclusions Higher fasting glucose(FPG≧6.1mmol/l) and gallbladder sludge may relate to the gallbladder stones after gastrectomy for gastric cancer, which could be treated with conservative method. Prophylactic cholecystectomy might be considered in patients with high fasting glucose preoperatively.