Analysis Of Risk Factors Of Acute Renal Injury In Patients With Decompensated Hepatitis B Cirrhosis

Objective: to investigate the clinical characteristics,risk factors and correlation of acute renal injury(Acute kidney injury,AKI)in patients with decompensated hepatitis B cirrhosis.Methods: the clinical data of patients with decompensated hepatitis B cirrhosis in our hospital were collected and divided into AKI group and non-AKI group.Univariate analysis and multivariate analysis were used to analyze the clinical data of patients with decompensated hepatitis B.The risk factors of acute renal injury in patients with decompensated hepatitis B cirrhosis were obtained.Results: 1.the incidence of AKI in patients with decompensated hepatitis B cirrhosis was 26.07%.Among them,AKI1 stage 73 cases(80.22%),AKI2 stage 12 cases(13.19%),AKI3 stage 6 cases(6.59%);2.the results of univariate analysis showed that age,serum bilirubin,AST,serum albumin,PT prolongation time,PTA,INR,serum sodium,procalcitonin,white blood cell count,hemoglobin,neutrophil percentage,C-reactive protein,procalcitonin,ascites,diuresis or ascites puncture,hepatic encephalopathy,gastrointestinal active hemorrhage,peritonitis,Child-Pugh grade,AKI group and non-AKI group.There was significant difference in MELD score.It is suggested that the above factors are the possible risk factors of AKI in patients with decompensated hepatitis B cirrhosis.3.the results of multivariate Logistic regression analysis showed that diuretic or ascites treatment,peritonitis,elevated procalcitonin,elevated neutrophil percentage and MELD score > 14 were independent risk factors for acute renal injury in patients with decompensated hepatitis B cirrhosis.Conclusion: the incidence of AKI in decompensated hepatitis B cirrhosis is high.Diuretic or ascites therapy,peritonitis,elevated procalcitonin,increased percentage of neutrophils and MELD score more than 14 are independent risk factors for acute renal injury in patients with decompensated hepatitis B cirrhosis.Therefore,for patients with hepatitis B cirrhosis with the above risk factors,it is necessary to guard against the occurrence of acute renal injury.