The Value Of Inflammatory Cytokines IL-8 And IL-12 In The Clinical Diagnosis Of Neurobrucellosis

Objective By analyzing the expression levels of IL-8 and IL-12 in peripheral serum and cerebrospinal fluid of patients with neurobrucellosis,the role of inflammatory cytokines in the immunopathology of neurobrucellosis was analyzed in order to investigate the disease the diagnosis and treatment of the disease provide ideas.Methods From January 2018 to December 2019,patients treated by the Affiliated Hospital of Inner Mongolia Medical University and the Centers for Comprehensive Disease Control and Prevention of Inner Mongolia Autonomous Region were selected.42 patients with neurobrucellosis were used as the experimental group.The control group included 34 cases of non-neurobrucellosis,24 patients with viral encephalitis,and 29 normal controls.All patients collected venous blood on an empty stomach after admission,and performed lumbar puncture to collect cerebrospinal fluid.The above samples were made in duplicate,and the levels of IL-8 and IL-12 in serum and cerebrospinal fluid were detected by MSD(Meso Scale Discovery)method.SPSS20.0 was used for statistical analysis.Results(1)Compared with the normal control group,the levels of IL-8 and IL-12 in the serum and cerebrospinal fluid of the neurobrucellosis group increased significantly(P<0.05).(2)Compared with the normal control group,the serum IL-8 level and IL-12 level in the non-neurobrucellosis group increased significantly(P<0.05).(3)Compared with the non-neurobrucellosis,the serum and cerebrospinal fluid IL-8 levels in neurobrucellosis group were significantly higher(P<0.05).(4)Compared with the viral encephalitis group,the serum IL-8 and IL-12 levels in the neurobrucellosis group increased significantly(P<0.05).Conclusion(1)IL-8 and IL-12 are highly expressed in Serum and CSF of neurobrucellosis,and play an important role in thepathogenesis of neurobrucellosis.(2)Inflammatory cytokine IL-8 is highly expressed specifically in neurobrucellosis,providing value for early diagnosis of neurobrucellosis.(3)Elevated levels of inflammatory cytokines IL-8 and IL-12 in serum provide evidence for the differential diagnosis of neurobrucellosis and viral encephalitis.