Correlation Between IL-2,IL-18,TNF-α And Neuropathic Brucellosis

Objective :To study the expression of IL-2、IL-18、 TNF-α in patients with cerebrospinal fluid(CSF)with brucellosis,non-invasive brucellosis,tuberculous meningitis,viral meningitis and healthy people.To explore the role of inflammatory cytokines in the immunopathology of neuropathic brucellosis,and determine the value of these factors in the diagnosis of neuropathic brucellosis,clinically Provide ideas for the diagnosis and treatment of neuropathic brucellosis.Method 38 patients with neurological brucellosis who were treated in Major hospitals in Inner Mongolia were selected as experimental group,and at the same time,24 cases of tuberculous meningitis,19 cases of viral meningitis,28 cases of brucellosis without involving the nervous system,and 23 cases of healthy people were selected as the control group.The expression of IL-2,IL-18 and TNF-α in cerebrospinal fluid was detected by MSD electrochemiluminescence detection.The data was analyzed by SPSS22.0 software.Results There was a statistically significant difference in the expression of inflammatory factors between the 5 groups(P<0.05).Perform a rank sum test of multiple sets of sample pairs,the expression of IL-2,IL-18 and TNF-α in cerebrospinal fluid of patients with brucellosis was higher than that of healthy people and Brucellosis patients who did not involve the nervous system,the difference was statistically significant(P<0.05).The expression of IL-2,IL-18 and TNF-α in cerebrospinal fluid of patients was not statistically significant between neurobuminosis and viral meningitis(P>0.05).The expression of IL-2,IL-18 and TNF-α in cerebrospinal fluid of patients with tuberculous meningitis was higher than that of neuropathic Brucellosis,and the difference was statistically significant(P<0.05).The expression of IL-2,IL-18 and TNF-α in cerebrospinal fluid of patients with tuberculous meningitis was higher than that of patients with viral meningitis,the difference was statistically significant(P<0.05).According to the correlation test,there was a positive correlation between the three groups of inflammatory cytokines.Conclusion IL-2,IL-18 and TNF-α are involved in the anti-neuropathic Brucellosis immune response.In the diagnosis ofneuropathic brucellosis,combined with the determination of the expression levels of inflammatory cytokines(IL-2,IL-18,TNF-α)in cerebrospinal fluid,it is helpful for the diagnosis of neuropathic brucellosis and the identification of tuberculous meningitis,which are worthy of clinical application.