| Objective: This subject lays a theoretical foundation for the further promotion of clinical application and the study of its mechanism of action by observing the clinical efficacy of Ziyu lip balm in the treatment of chronic cheilitis,and at the same time evaluating its safety for external use.Methods: Chronic cheilitis patients who met the diagnostic criteria and inclusion criteria in the dermatology clinic of the Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University were selected and divided into a treatment group and a control group.The clinical efficacy was observed according to the single-blind and controlled method.Yurun lip balm,the control group was rubbed with hydrocortisone butyrate cream.Before treatment,the first week of treatment,the second week of treatment,and the third week of treatment,the two groups were evaluated for clinical efficacy indicators(including the patient’s subjective symptoms,congestion / swelling,scaling,crusting,chapping,and lip skin symptoms);Before the treatment,the first week of treatment,the second week of treatment,the third week of treatment,skin barrier function tests(including skin cuticle water content,transdermal water loss,PH value);before treatment and the third week of treatment inflammatory factors Determination of IFN-γ content;observe whether the subject has adverse reactions during treatment,follow-up relapse after1 month of treatment.SPSS 20.0 statistical software was used forstatistical analysis of the data obtained during the test,and the observation indicators and safety of the treatment group and the control group before and after treatment were compared.Results:(1)A total of100 patients were enrolled from June 2019 to January 2020 in our hospital’s dermatology clinic,and 85 patients were finally completed,including 43 patients in the treatment group and 42 patients in the control group.There is no statistical difference on the general baseline(P> 0.05),and the two groups are equally balanced.(2)The scores of the five indicators of patients’ self-conscious symptoms,congestion / swelling,scaling / scabbing,chapping,and lip skin symptoms in the two groups at the first week of treatment,the second week of treatment,and the third week of treatment were all lower than those before treatment.After treatment,the scores of the two groups were statistically significant(P<0.05).The control group had better efficacy than the treatment group.(3)The total clinical effective rates of the treatment group and the control group were 79.07% and 97.62%,respectively.The clinical effectiveness of the two groups was statistically significant(P <0.05).The total clinical effective rate of the control group was higher than that of the treatment group.(4)After the first week of treatment,the second week of treatment,and the third week of treatment,the skin cuticle water content of the two groups of patients increased compared with before treatment,the amount of transcutaneous water loss decreased before treatment,and the skin PH value decreased compared with before treatment.The comparisonbetween the two groups after treatment was statistically significant(P<0.05),and the treatment group was better than the control group.(5)After the third week of treatment,the serum IFN-γ values of the two groups decreased compared with before treatment,but there was no statistically significant difference between the two groups in serum IFN-γ(P> 0.05).(6)During the entire treatment period,no adverse reactions related to the test drug occurred in the treatment group,and 3 cases of adverse reactions related to the test drug occurred in the control group.(7)Follow-up relapse rate 1 month after the end of treatment,the relapse rate of the treatment group was 5.90%,the relapse rate of the control group was 26.80%,and the relapse rate of the treatment group was lower than that of the control group.Conclusion:(1)Ziyu lip balm can reduce inflammation in patients with chronic cheilitis,improve clinical symptoms and skin barrier function.It has a significant role in increasing the water content of the stratum corneum,reducing the amount of transdermal water loss and lowering the skin PH value.(2)Ziyu lip balm has low recurrence rate for chronic cheilitis,good safety,and can be popularized and applied. |
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