Study On The Characteristics Of Traditional Chinese Medicine Syndrome Distribution And Medication Regularity In Sub-centimeter Pulmonary Nodule Based On Data Mining Technology

Objective:Using data mining analyses the symptoms and prescription drugs with sub-centimeter Pulmonary Nodule diagnosed and treated by Pro.Sun Zikai,in order to dig out the academic characteristics of common syndrome types,association of symptoms and drugs,teacher Sun’s clinical experience and medication regularity,enriching the sub-centimeter Pulmonary Nodule’s distribution of TCM syndromes,expecting teacher Sun’s experience guides the clinic better and provide a scientific and feasible basis for syndrome differentiation.Methods:Xminer Operation Tool data processing platform and SPSS26.0 technology were used for technical processing,against treating 150 cases of sub-centimeter Pulmonary Nodule by teacher Sun’s clinical Chinese medicine.establishing medical records database,applying analysis methods such as frequency statistics;association analysis and cluster analysis.Diging out the clinical symptoms of the patients and teacher Sun’s prescription drugs,in addition,the results of the excavation were analyzed and summarized in a "human-computer cooperative" manner.Results:1.The number of women is about 1.6 times that of men.With the increase of age between the ages of 20 and 70 years,the rate of detection and occurence of sub-centimeter Pulmonary Nodule is increasing.2.The frequency of TCM symptoms is ranked from high to low and the top ten sy mptoms are:dry mouth,dry cough,unfavorable throat,cough,shortness of breath,loose stools,white sputum,throat itching,fatigue and poor sleep.3.Based on the statistics of outpatient syndrome differentiation,it was found that qi-yin deficiency syndrome,yin asthenia generating intrinsic heat syndrome,spleen deficiency and liver depression syndrome,lung and spleen deficiency syndrome,qi deficiency of lung and Syndrome of positive deficiency and stasis account for 90.37%.Among them,75.33%of patients showed a single syndrome and 23.33%of patients showed a combination of both syndromes.4.High-frequency drugs with a frequency of more than 50%are arranged in descendi ng order,which are:hedyotis diffusa,ophiopogon,cochinchinese asparagus root,turtle shell,por ia cocos,adenophora tetraphylla,dandelion,semen coicis,radix paeoniae alba,milkvetch root,sculellaria barbata.The top eight frequency of drug efficacy categories are:yin-tonifying dr ugs,heat-clearing drugs,qi-tonifying drugs,diuretics for eliminating dampness,blood-enhancin g drugs,blood-enhancing stasis drugs,resolving hard lump drugs and qi-regulating drugs.To nic drugs are mainly yin-tonifying drugs and qi-tonifying drugs.5.In terms of support,the top ten results of clinical symptom internal association rule and have a meaningful combination,descending order are:dry mouth-dry cough,cough-whi te sputum,dry mouth-loose stools,throat itching-dry mouth,shortness of breath-dry mouth,po or sleep-dry mouth,shortness of breath-dry cough and unfavorable throat-cough.The results of intra-drug association suggest that:hedyotis diffusa-turtle shell,ophiopogon-cochinchines e asparagus root,adenophora tetraphylla-cochinchinese asparagus root and adenophora tetra phylla-ophiopogon as a combination of four commonly used drug pairs.6.In terms of clinical symptoms and drugs external association rule,setting the confid ence levels above 0.75 and having clinical significant results are:dry cough→asparagus,o phiopogon,hedyotis diffusa,adenophora tetraphylla,turtle shell,semen coicis;dry mouth→asp aragus,ophiopogon,turtle shell,adenophora tetraphylla;loose stools→semen coicis;unfavorabl e throat→pinellia,officinal magnolia bark,poria cocos,radix paeoniae alba.7.The clustering results of clinical symptoms and drugs were analyzed in a "human-computer cooperative" manner,which can be summarized into five combinations and five c ore prescription,and the two results have a one-to-one correspondence,specifically:The first combination of symptoms include shortness of breath,fatigue,dry cough,dry throat and dr y mouth;the second combination of symptoms include dry throat,dry mouth,and yellow sp utum;The third combination of symptoms include unfavorable throat and loose stools;The fourth combination of symptoms include shortness of breath,fatigue,cough.white sputum a nd loose stools;The fifth combination of symptoms include afraid of cold,dull complexion and chest pain.The first prescription of symptoms include heterophylly falsestarwort root,milkvetch root,ophiopogon,asparagus,semen dolichoris,tangerine peel,poria cocos,hedyotis di ffusa,dandelion,sculellaria barbata;The second prescription of symptoms include adenoph ora tetraphylla,ophiopogon,asparagus,noble dendrobium stem herb,fragrant solomonseal rhiz ome,rehmanniae radix,white mulberry root-bark,gardenia,semen coicis,Fritillaria verticillata Willd.var.thumbergii Bak,radix paeoniae alba,hedyotis diffusa,dandelion,sculellaria barbata,t urtle shell,tangerine peel and fried rice sprouts;The third prescription of symptoms include pinellia,officinal magnolia bark.poria cocos.tangerine peel,plum blossom,fried rice sprouts,semen dolichoris,semen coicis,heterophylly falsestarwort root,hedyotis diffusa,dandelion,co ptis root and medcinal evodia fruit;The fourth prescription of symptoms include tangshen,milkvetch root,heterophylly falsestarwort root,roasted atractylodes,tangerine peel,radix paeo niae alba,poria cocos,chinese angelica,hedyotis diffusa,divaricate saposhniovia root,schisan dra and liquorice root;The fifth prescription of symptoms include heterophylly falsestarwo rt root,asparagus,ophiopogon,lucid ganoderma,lily root,hedyotis diffusa,turtle shell,acrugino us turmeric rhizome,sarcandra glabra,dandelion,sculellaria barbata,chinese angelica,radix pa eoniae alba,rehmannia glutinosa,semen coicis,semen dolichoris,poria cocos.Conclusion:1.Patients with sub-centimeter Pulmonary Nodule are more common in women,the in cidence rate of nodules is positively related to age.2.According to the statistical results of symptom frequency,it indicated that sub-centi meter Pulmonary Nodule were mainly characterized by qi deficiency,blood deficiency,yin deficiency,lung deficiency,spleen deficiency and liver depression.3.Patients with sub-centimeter Pulmonary Nodule are mainly characterized by qi-yin deficiency syndrome,yin asthenia generating intrinsic heat syndrome,spleen deficiency and liver depression syndrome and lung and spleen deficiency syndrome.Among them,most of them manifested as a single syndrome and some of them can manifested as two or even multiple types of syndromes.4.Characteristics of medication:①attaching great importance to replenishing and tonifying deficiency,especially to nourish qi and spleen,nourish lungs and moistening lungs;(2)Paying attention to recuperate balance,so that qi is smooth with blood is flowing and the body reaches a state of yin-yang balance;③attaching great importance to syndrome differentiation and examine the cause of drug application,cleverly integrating the thoughts of "syndrome differentiation" and"disease differentiation" to guide clinical treatment and use drugs;④Both safety and efficacy are taken into consideration,paying attention to the efficacy of medication and more attention to the safety,so the drugs is more peaceful;⑤The pharmacological research of traditional Chinese medicine is emphasized to make the prescription more scientific.At the same time,teacher Sun focuses on relieving the patient’s psychology,listening to the patient’s psychological anxiety and tell patients to treat the sub-centimeter Pulmonary Nodule with normalmentality,which often can achieve more effects with less effort.5.①hedyotis diffusa-turtle shell;②ophiopogon-asparagus;③adenophora tetraphylla-aspa ragus;④adenophora tetraphylla-ophiopogon,these are four commonly used drug pair combi nation.6.Five types of syndromes were clustered.Common syndrome types are qi-yin deficiency syndrome,yin asthenia generating intrinsic heat syndrome,spleen deficiency and liver depression syndrome and lung and spleen deficiency syndrome,although a few patients manifested as Syndrome of positive deficiency and stasis.7.Five types of prescriptions were clustered.The treatment methods are reinforcing qi and nourishing yin,resolving toxin and dissipating binds;clearing heat and nourishing yin,producing saliva embellish dryness,supplemented with dissipating binds;promoting qi circulation and relieving depression,invigorating spleen to remove phlem;reinforcing lung to consolidate the exterior,nourishing qi and spleen and tonifying deficiency,supplementeding with removing phlem,promoting blood circulation,and dissipating binds.