Clinical Observation Of Huangzi Cream In The Treatment Of Chronic Localized Eczema

ObjectivesCoptis chinensis and lithospermum erythrorhizon has a long history and is widely used in dermatology.The purpose of this study was to explore the clinical efficacy and safety evaluation of self-formulated Huangzi cream(the main components are coptis chinensis and lithospermum erythrorhizon)in the treatment of chronic localized eczema.Methods1.40 patients with chronic localized eczema(skin lesion area≤5% of body surface area)were collected;2.40 patients were randomly divided into groups in a 1:1 ratio using random,control and parallel methods,20 patients in the experimental group and the control group,respectively.There was no statistically significant difference in age,gender and disease course between the two groups(all had P>0.05).3.The experimental group was given self-formulated Huangzi cream for external application,and the control group was given0.1% hydrocortisone butyrate cream(product name: yuzhuoer;manufacturer: Tianjin jinyao pharmaceutical co.LTD;production batch number: H10940095;specification: 30g/piece)for external application;4.Course of treatment: the course of treatment for both groups was 4 weeks;5.To observe the changes of skin lesions symptoms and signs and skin barrier function before and after treatment for 4 weeks.Visual analogy scale(VAS)was used for symptom evaluation.The signs were evaluated with reference to the improved Eczema area and severity index(EASI)score.The main indicators were erythema,indentation(edema)/papules,lichenization,exudation/scab,epiderm al peeling and skin lesion area/baseline area.The skin barrier function measurements include:Transepidermal(TEWL),Water content of stratum corneum(WCSC).6.The data were described by means of standard deviation(`X±S)and statistically processed by SPSS 24.0 statistical software.The k-s test of a single sample was firstly used to analyze whether the data conforms to the normal distribution.Paired T test was used to compare the mean value before and after treatment in the same group.Mann-whitney U test was used to analyze the data that did not conform to normal distribution.Chi-square test was used to compare gender composition between groups.All tests were conducted on both sides,and the level was 0.05.All results were evaluated with P<0.05 as the standard,and the difference was considered statistically significant.Research resultsHuangzi cream has therapeutic effect on chronic localized eczema,and its curative effect is similar to 0.1% hydrocortisone butyrate cream.Experimental group: 1 case was lost,1 case was removed,18 cases were completed,3cases were cured,7 cases were effective,6 cases were effective,and 2 case was invalid.The goodimprovement rate was 55.56%,and the overall efficiency was88.89%.Control group: 2 cases of shedding,18 cases of completion,2 cases of recovery,4 cases of obvious effect,10 cases of effective effect,2 cases of ineffective effect,The good improvement rate was 33.33%,and the overrall efficiency was 88.89%.There was no significant difference in the good improvement rate between the two groups(P>0.05).The total EASI score of patients with chronic localized eczema was improved at 2 weeks and 4 weeks before and after treatment in both groups,and it was statistically significant compared with that before treatment(P<0.01).At 2 weeks and 4 weeks,all indicators of EASI score,including erythema,induration/papule,lichenization,exudation/scab,epidermal peeling and skin lesion area,were significantly improved in the test group,and the results were statistically significant compared with those before treatment(P<0.05).In the control group,there was no significant difference in the improvement of lichenization of erythema and skin lesions at 2 weeks and lichenization of skin lesions at 4 weeks(P>0.05).4 weeks after treatment compared the two groups: treatment group in patients with limitation of chronic eczema induration(edema)/papula is better than that of control group(P<0.05),and other indicators EASI scores including erythema,induration/pimples,seep/scabby,there was no significant difference between the two groups(P > 0.05).VAS score of pruritus was significantly decreased before and after treatment in both groups,and it was statistically significant compared with that before treatment(P<0.01).There was no significant difference in VAS scores between the two groups(P>0.05).Conclusion: Huangzi cream is effective in the treatment of chroniclocalized eczema,and it is better than hydrocortisone butyrate cream in the treatment of hypertrophic skin rash.It is safe and provides a new choice for topical medicine of chronic localized eczema.