Potential Nutrition And Inflammation-related Markers For Predicting The Chemotherapeutic Outcomes And Prognosis Of Patients With Metastatic Colorectal Cancer

Objective: The purpose of this study was to explore whether pretreatment potential nutrition and inflammation-related markers are related to chemotherapeutic outcomes and prognosis of in-patients with metastatic colorectal cancer(mCRC)undergoing chemotherapy.Methods: Data from 71 patients with mCRC were analyzed retrospectively.The relationship between the potential nutrition and inflammation-related markers before first-line chemotherapy and clinicopathological characteristics and chemotherapy effects of the patients were calculated using Fisher’s exact test and the chi-square test.The prognostic factors were analyzed using univariate and multivariate analyses.We analyzed the subgroups using the Mann–Whitney U-test.Results: Four factors were eventually used as prognostic factors,namely the albumin to globulin ratio(AGR),the fibrinogen to albumin ratio(FAR),the prealbumin to globulin ratio(PGR),and the fibrinogen to prealbumin ratio(FPR).The cut-off values of the four potential prognostic factors were 1.40,10.63,5.44,and 18.49,respectively.The high AGR and PGR groups had a higher treatment response rate than that of the low groups.Patients in the low FAR and FPR groups showed a higher objective response rate than those in the high FAR and FPR groups.Low FPR was associated with a higher disease control rate compared with a high FPR.Higher progressive free survival(PFS)rates were observed in the high AGR and PGR and low FAR and FPR groups.AGR,FAR,PGR,and FPR were considered reliable prognostic factors for PFS in a univariate analysis.Conclusions: The prechemotherapy AGR,FAR,PGR,and FPR were good prognostic factors to predict the chemotherapy response and PFS in patients with mCRC.