The C-reactive Protein-to-prealbumin Ratio Predicts Prognoses Of Patients After Curative Resection For Hepatocellular Carcinoma

Objective: To evaluate the prognostic significance of C-reactive Protein-toPrealbumin ratio(CPR)on patients with Hepatocellular Carcinoma(HCC)in this study.and to investigate the association between C-reactive Protein、Prealbumin、CRP and clinicopathologic parameters in HCC patients.Methods: 142 HCC patients were retrospectively analyzed,who received curative resection in the first affiliated hospital of Bengbu medical college from January 2013 to December 2015.Receiver operating characteristic curve(ROC curve)was used to determine the optimal cut-offs for these biomarkers.Correlations between C-reactive Protein-to-Prealbumin ratio and clinicopathologic characteristics were analyzed by χ 2 test.In addition,Kaplan-Meier survival analysis were applied for prognostic analyses.Univariate survival analysis was performed using a Log rank test.Multivariate analysis using the Cox regression proportional hazard model was performed to identify the factors associated with the prognosis.Results:An optimal cutoff value of the preoperative C-reactive Protein-to-Prealbumin ratio(4.666)was determined via a ROC curve analysis.The median survival time(MST)of patients between the high CPR group and the low CPR group was 14 months and 38 months.By comparing the preoperative clinicopathological characteristics of the high CPR group and the low CPR group,we found CPR was significantly correlated with Tumor diameter、China Liver cancer staging、Prealbumin and CRP,(P<0.05)。The univariate analysis demonstrated that Hepatic Cirrhosis、HBs Ag、Tumor diameter、The number of tumors、China Liver cancer staging、Prealbumin、C-reactive Protein and C-reactive Protein-to-Prealbumin ratio(CPR),were associated with Overall survival(OS)(P<0.05).The multivariate analysis found that Tumor diameter and CPR as independent prognostic factors in patients with HCC(P<0.05).Conclusion: The preoperative C-reactive Protein-to-Prealbumin ratio is an effective prognostic factor for HCC patients who underwent curative resection.An elevated f Creactive Protein-to-Prealbumin ratio significantly correlates with poorer survival in HCC patients.